Setting description

Equal randomization: Carboplatin more effective in the DRD+ biomarker signature (cfr scen 6)

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 4 2 13 19
TP53- & AR- 9 11 134 151
TP53+ 6 5 25 27
DRD+ 0 0 322 321
TEfus+ 4 2 24 24
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.008 0.004 0.026 0.038
TP53- & AR- 0.018 0.022 0.268 0.302
TP53+ 0.012 0.010 0.050 0.054
DRD+ 0.000 0.000 0.644 0.642
TEfus+ 0.008 0.004 0.048 0.048
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 6 4 1 0
TP53- & AR- 203 216 9 6
TP53+ 75 49 2 1
DRD+ 173 160 0 0
TEfus+ 64 45 1 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.012 0.008 0.002 0.000
TP53- & AR- 0.406 0.432 0.018 0.012
TP53+ 0.150 0.098 0.004 0.002
DRD+ 0.346 0.320 0.000 0.000
TEfus+ 0.128 0.090 0.002 0.004
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 7 6 6 15
TP53+ 7 17 4 9
DRD+ 0 0 0 0
TEfus+ 1 0 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.014 0.012 0.012 0.030
TP53+ 0.014 0.034 0.008 0.018
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.002 0.000 0.000 0.000


Errors & power

The overall error was 0.276.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.044             0.036             0.126             0.110 

The overall power was 0.872.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.000             0.644             0.642 

Median results at the end of the trial

By signature:
signature var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
all graduation 13 0 4 19 2
futility 1 0 6 0 4
max_n 0 0 0 0 0
n 227 (164, 275) 278 (246, 321) 217 (145, 280) 224 (155, 282) 225 (157, 286)
n_unique 209 (152, 255) 254 (226, 292) 200 (134, 260) 204 (143, 260) 208 (143, 266)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop 12 (5, 28) NA (NA, NA) 6 (4, 21) 22 (5, 34) 4 (4, 26)
post_p 1 (0.94, 1) NA (NA, NA) 0.42 (0.08, 0.85) 1 (0.94, 1) 0.46 (0.1, 0.9)
rate 0.083 (0.073, 0.093) 0.113 (0.102, 0.122) 0.113 (0.103, 0.126) 0.082 (0.072, 0.093) 0.112 (0.101, 0.124)
DRD+ graduation 322 0 0 321 0
futility 0 0 173 0 160
max_n 0 0 0 0 0
n 53 (26, 85) 85 (67, 107) 62 (29, 91) 53 (26, 87) 66 (31, 98)
n_unique 47 (23, 76) 78 (61, 100) 56 (26, 84) 47 (24, 80) 60 (28, 90)
time_trial 30 (15, 36) 36 (36, 36) 36 (19, 36) 29 (15, 36) 36 (19, 36)
time_stop 22 (14, 33) NA (NA, NA) 23 (13, 33) 21 (13, 34) 23 (15, 34)
post_p 1 (1, 1) NA (NA, NA) 0.27 (0.05, 0.73) 1 (1, 1) 0.3 (0.03, 0.7)
rate 0.036 (0.028, 0.046) 0.113 (0.097, 0.131) 0.115 (0.093, 0.141) 0.036 (0.026, 0.045) 0.113 (0.094, 0.141)
TEfus+ graduation 24 0 4 24 2
futility 1 0 64 2 45
max_n 0 0 1 0 0
n 81 (57, 107) 105 (88, 126) 81 (39, 108) 82 (56, 108) 87 (53, 112)
n_unique 74 (52, 98) 96 (80, 116) 75 (36, 98) 75 (49, 98) 80 (49, 103)
time_trial 36 (36, 36) 36 (36, 36) 36 (25, 36) 36 (36, 36) 36 (36, 36)
time_stop 15 (10, 27) NA (NA, NA) 15 (11, 32) 14 (10, 24) 20 (12, 30)
post_p 0.99 (0.86, 1) NA (NA, NA) 0.41 (0.06, 0.82) 0.99 (0.83, 1) 0.42 (0.09, 0.86)
rate 0.074 (0.061, 0.089) 0.112 (0.099, 0.13) 0.114 (0.096, 0.139) 0.074 (0.06, 0.089) 0.112 (0.095, 0.133)
TP53- & AR- graduation 134 0 9 151 11
futility 9 0 203 6 216
max_n 6 0 7 15 6
n 95 (31, 126) 119 (97, 144) 88 (28, 123) 92 (29, 129) 90 (28, 126)
n_unique 88 (29, 117) 109 (89, 133) 83 (27, 115) 86 (26, 120) 85 (26, 119)
time_trial 36 (14, 36) 36 (36, 36) 36 (12, 36) 36 (12, 36) 36 (12, 36)
time_stop 17 (9, 29) NA (NA, NA) 16 (10, 30) 15 (9, 29) 17 (10, 31)
post_p 0.95 (0.62, 1) NA (NA, NA) 0.41 (0.09, 0.84) 0.96 (0.61, 1) 0.41 (0.08, 0.84)
rate 0.085 (0.07, 0.104) 0.113 (0.099, 0.128) 0.114 (0.097, 0.14) 0.084 (0.067, 0.102) 0.114 (0.097, 0.143)
TP53+ graduation 25 0 6 27 5
futility 2 0 75 1 49
max_n 4 0 7 9 17
n 103 (77, 124) 120 (102, 144) 104 (47, 127) 103 (78, 129) 108 (70, 133)
n_unique 95 (70, 115) 109 (93, 130) 95 (43, 117) 95 (71, 118) 100 (63, 124)
time_trial 36 (36, 36) 36 (36, 36) 36 (21, 36) 36 (36, 36) 36 (34, 36)
time_stop 17 (10, 26) NA (NA, NA) 17 (9, 30) 16 (9, 29) 18 (9, 31)
post_p 0.96 (0.74, 1) NA (NA, NA) 0.4 (0.1, 0.81) 0.96 (0.7, 1) 0.46 (0.11, 0.86)
rate 0.084 (0.071, 0.098) 0.113 (0.099, 0.128) 0.114 (0.1, 0.135) 0.084 (0.07, 0.099) 0.113 (0.098, 0.13)


By subgroup combinations:
subtype var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
—- graduation 152 0 218 165 231
futility 0 0 0 0 0
max_n 6 0 7 15 6
n 62 (21, 83) 71 (55, 92) 56 (17, 75) 60 (19, 82) 54 (18, 78)
n_unique 58 (19, 78) 65 (51, 85) 53 (16, 72) 56 (17, 77) 52 (17, 73)
post_p 0.54 (0.14, 0.88) NA (NA, NA) 0.49 (0.11, 0.88) 0.55 (0.11, 0.86) 0.46 (0.1, 0.87)
rate 0.112 (0.093, 0.134) 0.113 (0.094, 0.134) 0.113 (0.094, 0.144) 0.112 (0.092, 0.135) 0.115 (0.093, 0.147)
—+ graduation 165 0 241 178 248
futility 0 0 0 0 0
max_n 6 0 8 15 6
n 12 (3, 19) 15 (10, 22) 10 (3, 17) 12 (3, 19) 10 (3, 19)
n_unique 11 (3, 18) 14 (8, 20) 9 (3, 16) 10 (3, 17) 9 (3, 17)
post_p 0.52 (0.18, 0.84) NA (NA, NA) 0.5 (0.18, 0.82) 0.52 (0.19, 0.82) 0.47 (0.18, 0.84)
rate 0.11 (0.072, 0.17) 0.115 (0.078, 0.172) 0.117 (0.078, 0.212) 0.112 (0.07, 0.17) 0.117 (0.079, 0.22)
–+- graduation 40 0 88 44 58
futility 0 0 0 0 0
max_n 4 0 7 9 17
n 35 (26, 45) 37 (29, 47) 34 (15, 44) 36 (25, 45) 35 (23, 44)
n_unique 33 (24, 42) 34 (26, 44) 32 (15, 41) 33 (23, 42) 32 (21, 42)
post_p 0.53 (0.16, 0.88) NA (NA, NA) 0.5 (0.13, 0.85) 0.49 (0.14, 0.87) 0.52 (0.16, 0.88)
rate 0.113 (0.088, 0.143) 0.114 (0.089, 0.143) 0.115 (0.09, 0.153) 0.115 (0.087, 0.145) 0.113 (0.089, 0.146)
–++ graduation 59 0 139 63 92
futility 0 0 0 0 0
max_n 4 0 7 9 17
n 24 (15, 32) 25 (19, 35) 22 (8, 31) 24 (14, 32) 23 (12, 32)
n_unique 22 (14, 30) 23 (16, 32) 21 (7, 28) 22 (13, 30) 21 (11, 29)
post_p 0.5 (0.15, 0.86) NA (NA, NA) 0.47 (0.15, 0.84) 0.53 (0.14, 0.84) 0.51 (0.16, 0.86)
rate 0.113 (0.083, 0.152) 0.113 (0.084, 0.152) 0.118 (0.084, 0.167) 0.112 (0.083, 0.151) 0.112 (0.086, 0.156)
-+– graduation 378 0 302 373 299
futility 0 0 0 0 0
max_n 6 0 7 12 6
n 9 (3, 17) 16 (9, 23) 10 (3, 20) 9 (3, 17) 10 (3, 19)
n_unique 8 (3, 16) 14 (9, 21) 9 (3, 18) 8 (3, 16) 9 (3, 18)
post_p 0.94 (0.75, 0.99) NA (NA, NA) 0.3 (0.09, 0.66) 0.94 (0.71, 1) 0.31 (0.08, 0.62)
rate 0.036 (0.017, 0.063) 0.114 (0.079, 0.168) 0.119 (0.077, 0.206) 0.036 (0.015, 0.067) 0.119 (0.078, 0.227)
-+-+ graduation 383 0 316 376 309
futility 0 0 0 0 0
max_n 6 0 8 12 6
n 9 (3, 17) 16 (10, 23) 9 (3, 20) 8 (3, 18) 10 (3, 20)
n_unique 8 (2, 16) 15 (9, 22) 8 (2, 18) 8 (3, 16) 9 (3, 18)
post_p 0.93 (0.71, 0.99) NA (NA, NA) 0.31 (0.08, 0.63) 0.94 (0.72, 1) 0.3 (0.1, 0.65)
rate 0.037 (0.016, 0.066) 0.111 (0.078, 0.166) 0.121 (0.076, 0.222) 0.036 (0.016, 0.062) 0.117 (0.076, 0.211)
-++- graduation 340 0 232 328 193
futility 0 0 0 0 0
max_n 2 0 6 9 17
n 5 (2, 10) 9 (5, 13) 7 (2, 12) 6 (2, 11) 7 (3, 13)
n_unique 5 (1, 9) 8 (4, 12) 6 (2, 11) 5 (2, 11) 6 (2, 12)
post_p 0.84 (0.59, 0.97) NA (NA, NA) 0.32 (0.11, 0.63) 0.87 (0.59, 0.98) 0.32 (0.11, 0.64)
rate 0.037 (0.014, 0.085) 0.118 (0.072, 0.192) 0.123 (0.072, 0.242) 0.034 (0.014, 0.072) 0.119 (0.072, 0.217)
-+++ graduation 346 0 259 334 210
futility 0 0 0 0 0
max_n 2 0 6 9 17
n 5 (2, 11) 9 (5, 13) 6 (1, 11) 6 (2, 11) 7 (2, 13)
n_unique 5 (2, 10) 8 (4, 12) 6 (1, 10) 5 (2, 10) 6 (2, 12)
post_p 0.86 (0.59, 0.97) NA (NA, NA) 0.33 (0.12, 0.63) 0.85 (0.59, 0.98) 0.34 (0.1, 0.62)
rate 0.035 (0.015, 0.073) 0.115 (0.07, 0.194) 0.121 (0.069, 0.256) 0.034 (0.013, 0.072) 0.118 (0.065, 0.219)
+— graduation 14 0 10 19 6
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (7, 17) 12 (8, 17) 12 (8, 17) 12 (7, 17) 12 (8, 17)
n_unique 11 (6, 16) 11 (7, 16) 11 (6, 16) 11 (6, 16) 11 (7, 16)
post_p 0.48 (0.16, 0.86) NA (NA, NA) 0.49 (0.18, 0.82) 0.5 (0.15, 0.81) 0.52 (0.18, 0.85)
rate 0.116 (0.072, 0.182) 0.114 (0.073, 0.171) 0.115 (0.075, 0.176) 0.116 (0.076, 0.182) 0.113 (0.074, 0.177)
+–+ graduation 38 0 76 43 51
futility 0 0 0 0 0
max_n 0 0 1 0 0
n 9 (5, 14) 10 (6, 14) 9 (4, 14) 9 (5, 14) 9 (5, 14)
n_unique 8 (5, 13) 9 (5, 13) 8 (4, 13) 8 (4, 13) 8 (4, 13)
post_p 0.5 (0.18, 0.81) NA (NA, NA) 0.48 (0.19, 0.8) 0.5 (0.17, 0.83) 0.51 (0.18, 0.85)
rate 0.113 (0.071, 0.192) 0.115 (0.071, 0.186) 0.117 (0.077, 0.202) 0.115 (0.069, 0.185) 0.112 (0.068, 0.193)
+-+- graduation 40 0 88 44 58
futility 0 0 0 0 0
max_n 4 0 7 9 17
n 10 (5, 14) 10 (6, 14) 9 (4, 13) 10 (5, 14) 9 (5, 14)
n_unique 9 (5, 13) 9 (5, 13) 8 (4, 12) 9 (5, 13) 9 (4, 13)
post_p 0.5 (0.18, 0.82) NA (NA, NA) 0.48 (0.15, 0.78) 0.52 (0.17, 0.81) 0.5 (0.18, 0.82)
rate 0.112 (0.068, 0.201) 0.11 (0.069, 0.179) 0.118 (0.073, 0.215) 0.116 (0.07, 0.184) 0.115 (0.071, 0.19)
+-++ graduation 59 0 139 63 92
futility 0 0 0 0 0
max_n 4 0 7 9 17
n 9 (4, 15) 10 (6, 16) 9 (3, 14) 10 (4, 14) 9 (4, 15)
n_unique 8 (4, 13) 10 (6, 15) 8 (2, 13) 8 (4, 13) 9 (3, 14)
post_p 0.5 (0.19, 0.82) NA (NA, NA) 0.48 (0.17, 0.82) 0.51 (0.18, 0.82) 0.53 (0.16, 0.83)
rate 0.115 (0.066, 0.197) 0.114 (0.075, 0.183) 0.121 (0.073, 0.212) 0.113 (0.066, 0.192) 0.112 (0.069, 0.204)
++– graduation 331 0 182 327 164
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 5 (2, 11) 9 (5, 13) 7 (2, 12) 6 (2, 11) 7 (3, 12)
n_unique 5 (2, 10) 8 (4, 12) 6 (2, 11) 5 (2, 9) 7 (2, 11)
post_p 0.84 (0.55, 0.97) NA (NA, NA) 0.34 (0.1, 0.62) 0.85 (0.55, 0.97) 0.34 (0.11, 0.62)
rate 0.039 (0.012, 0.079) 0.117 (0.07, 0.191) 0.118 (0.07, 0.232) 0.039 (0.011, 0.078) 0.118 (0.067, 0.223)
++-+ graduation 339 0 216 334 186
futility 0 0 0 0 0
max_n 0 0 1 0 0
n 5 (2, 11) 9 (5, 13) 7 (2, 12) 5 (2, 11) 7 (3, 12)
n_unique 5 (2, 10) 8 (4, 12) 6 (2, 11) 5 (2, 9) 7 (3, 12)
post_p 0.85 (0.56, 0.98) NA (NA, NA) 0.34 (0.12, 0.63) 0.85 (0.58, 0.97) 0.34 (0.12, 0.65)
rate 0.037 (0.013, 0.077) 0.116 (0.071, 0.206) 0.121 (0.067, 0.232) 0.037 (0.014, 0.082) 0.116 (0.064, 0.199)
+++- graduation 340 0 232 328 193
futility 0 0 0 0 0
max_n 2 0 6 9 17
n 5 (2, 10) 9 (5, 14) 6 (2, 11) 5 (2, 11) 7 (2, 11)
n_unique 4 (2, 9) 8 (4, 13) 6 (2, 10) 5 (1, 10) 6 (2, 11)
post_p 0.83 (0.56, 0.97) NA (NA, NA) 0.35 (0.13, 0.65) 0.86 (0.55, 0.97) 0.33 (0.11, 0.66)
rate 0.036 (0.014, 0.079) 0.119 (0.068, 0.197) 0.12 (0.064, 0.228) 0.036 (0.012, 0.077) 0.116 (0.067, 0.215)
++++ graduation 346 0 259 334 210
futility 0 0 0 0 0
max_n 2 0 6 9 17
n 5 (2, 10) 9 (5, 14) 6 (2, 13) 5 (2, 11) 7 (2, 12)
n_unique 5 (1, 9) 8 (5, 13) 6 (1, 11) 5 (1, 10) 6 (2, 11)
post_p 0.85 (0.52, 0.98) NA (NA, NA) 0.34 (0.12, 0.64) 0.85 (0.59, 0.97) 0.32 (0.11, 0.62)
rate 0.038 (0.012, 0.085) 0.114 (0.067, 0.209) 0.122 (0.068, 0.242) 0.038 (0.013, 0.077) 0.121 (0.07, 0.248)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 4 2 13 19
time_stop 4 (4, 5) 4 (4, 4) 15 (6, 28) 22 (5, 34)
n_trt 26 (25, 28) 29 (28, 30) 87 (36, 178) 107 (31, 182)
n_control 26 (18, 31) 25 (23, 27) 102 (40, 214) 156 (30, 254)
post_p 0.89 (0.85, 0.92) 0.91 (0.88, 0.93) 0.99 (0.96, 1) 1 (0.97, 1)
order 1 (1, 1) 1 (1, 1) 1 (1, 3.8) 3 (1, 4)
TP53- & AR- count 9 11 134 151
time_stop 12 (10, 14) 12 (10, 19) 18 (9, 29) 15 (9, 30)
n_trt 33 (27, 38) 27 (25, 43) 48 (26, 92) 40 (26, 86)
n_control 32 (25, 43) 36 (26, 57) 51 (22, 90) 44 (24, 91)
post_p 0.93 (0.88, 0.97) 0.93 (0.86, 0.97) 0.96 (0.9, 1) 0.97 (0.9, 1)
order 1 (1, 2) 2 (1, 3) 2 (1, 3) 1 (1, 3)
TP53+ count 6 5 25 27
time_stop 8 (7, 9) 10 (9, 11) 18 (9, 27) 16 (10, 29)
n_trt 26 (25, 29) 30 (27, 33) 46 (25, 78) 48 (27, 86)
n_control 20 (20, 26) 35 (28, 38) 57 (23, 93) 52 (27, 96)
post_p 0.93 (0.9, 0.97) 0.96 (0.94, 0.97) 0.99 (0.94, 1) 0.98 (0.96, 1)
order 1 (1, 1) 2 (1, 2) 2 (1, 4) 2 (1, 3)
DRD+ count 322 321
time_stop 22 (14, 33) 21 (13, 34)
n_trt 39 (25, 74) 37 (26, 69)
n_control 45 (24, 79) 43 (25, 74)
post_p 1 (0.99, 1) 1 (0.99, 1)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 4 2 24 24
time_stop 13 (9, 16) 12 (12, 13) 14 (10, 28) 15 (10, 24)
n_trt 30 (26, 40) 26 (25, 28) 32 (27, 53) 30 (25, 51)
n_control 28 (23, 50) 34 (32, 36) 40 (23, 75) 40 (27, 72)
post_p 0.94 (0.87, 0.97) 0.95 (0.91, 0.99) 0.98 (0.92, 1) 1 (0.96, 1)
order 1.5 (1, 2.7) 2.5 (1.3, 3.7) 2 (1, 3) 2 (1, 3)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 6 4 1
time_stop 13 (6, 25) 14 (4, 28) 4 (4, 4)
n_trt 65 (40, 142) 77 (29, 153) 30 (30, 30)
n_control 94 (37, 196) 110 (29, 236) 29 (29, 29)
post_p 0.05 (0.02, 0.17) 0.03 (0.01, 0.09) 0.09 (0.09, 0.09)
order 2 (1, 3.5) 3.5 (1, 6) 1 (1, 1)
TP53- & AR- count 203 216 9 6
time_stop 17 (10, 30) 17 (10, 31) 10 (9, 14) 11 (10, 18)
n_trt 43 (26, 86) 44 (26, 92) 26 (25, 32) 27 (26, 42)
n_control 46 (23, 95) 46 (24, 100) 28 (24, 37) 32 (24, 46)
post_p 0.16 (0.05, 0.26) 0.16 (0.04, 0.28) 0.16 (0.03, 0.23) 0.18 (0.09, 0.25)
order 1 (1, 3) 1 (1, 3) 1 (1, 1.2) 1 (1, 3)
TP53+ count 75 49 2 1
time_stop 18 (9, 30) 19 (9, 32) 11 (11, 11) 8 (8, 8)
n_trt 47 (28, 96) 59 (27, 100) 28 (26, 31) 28 (28, 28)
n_control 49 (26, 102) 58 (25, 104) 34 (32, 37) 13 (13, 13)
post_p 0.09 (0.02, 0.19) 0.09 (0.02, 0.19) 0.1 (0.07, 0.13) 0.21 (0.21, 0.21)
order 2 (1, 3) 2 (1, 3) 1 (1, 1) 1 (1, 1)
DRD+ count 173 160
time_stop 23 (13, 33) 23 (15, 34)
n_trt 41 (26, 68) 42 (26, 71)
n_control 47 (24, 79) 46 (27, 78)
post_p 0.08 (0.01, 0.22) 0.08 (0.01, 0.22)
order 2 (1, 4) 2 (1, 4)
TEfus+ count 64 45 1 2
time_stop 15 (11, 33) 20 (12, 30) 18 (18, 18) 9 (8, 10)
n_trt 36 (25, 75) 47 (30, 75) 47 (47, 47) 26 (25, 27)
n_control 37 (23, 96) 52 (28, 91) 45 (45, 45) 22 (18, 26)
post_p 0.06 (0, 0.17) 0.07 (0.02, 0.19) 0.08 (0.08, 0.08) 0.05 (0.04, 0.06)
order 2 (1, 4) 2 (1, 4) 1 (1, 1) 1 (1, 1)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Carboplatin count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
time 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28) 15 (6, 28)
n 14 (8, 40) 5 (1, 10) 13 (6, 29) 6 (2, 24) 3 (1, 8) 3 (1, 9) 3 (0, 7) 3 (0, 7) 5 (1, 12) 3 (1, 8) 4 (0, 7) 3 (0, 8) 2 (0, 6) 2 (0, 6) 3 (0, 6) 3 (1, 6)
post_p 0.68 (0.52, 0.9) 0.64 (0.53, 0.77) 0.63 (0.53, 0.77) 0.57 (0.52, 0.71) 0.61 (0.51, 0.86) 0.66 (0.52, 0.86) 0.65 (0.53, 0.85) 0.69 (0.53, 0.86) 0.67 (0.55, 0.96) 0.56 (0.51, 0.79) 0.7 (0.56, 0.89) 0.58 (0.55, 0.74) 0.62 (0.58, 0.89) 0.72 (0.56, 0.88) 0.59 (0.52, 0.84) 0.75 (0.56, 0.88)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.085 (0.063, 0.096) 0.071 (0, 0.106) 0.1 (0.05, 0.13) 0.087 (0.008, 0.131) 0.034 (0, 0.097) 0.023 (0, 0.052) 0.015 (0, 0.063) 0.021 (0, 0.072) 0.034 (0, 0.109) 0.087 (0, 0.134) 0.048 (0, 0.071) 0.084 (0, 0.129) 0.011 (0, 0.064) 0 (0, 0.036) 0 (0, 0.078) 0 (0, 0.043)
Hormone_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5)
n 7 (6, 9) 0 (0, 2) 4 (2, 5) 2 (1, 4) 0 (0, 1) 1 (1, 2) 0 (0, 1) 0 (0, 2) 0 (0, 2) 2 (0, 2) 1 (1, 2) 2 (0, 3) 0 (0, 2) 1 (0, 2) 2 (1, 2) 0 (0, 2)
post_p 0.67 (0.56, 0.76) 0.88 (0.88, 0.88) 0.69 (0.63, 0.79) 0.58 (0.56, 0.62) 0.59 (0.57, 0.61) 0.61 (0.55, 0.66) 0.52 (0.52, 0.52) 0.78 (0.78, 0.78) 0.66 (0.61, 0.71) 0.7 (0.67, 0.74) 0.56 (0.56, 0.56) 0.57 (0.57, 0.57) NA (NA, NA) 0.56 (0.56, 0.56) 0.56 (0.53, 0.59) 0.67 (0.67, 0.67)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.054 (0.015, 0.1) 0.09 (0.09, 0.09) 0 (0, 0.05) 0 (0, 0) 0 (0, 0) 0 (0, 0.303) 0.191 (0.191, 0.191) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1.006) 0 (0, 0.245) 0.227 (0.045, 0.408) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19
time 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34) 22 (5, 34)
n 21 (6, 51) 4 (1, 15) 18 (4, 31) 9 (3, 21) 5 (2, 8) 3 (1, 10) 3 (1, 7) 2 (0, 7) 6 (1, 12) 6 (1, 10) 5 (1, 12) 4 (1, 11) 3 (1, 6) 4 (2, 7) 3 (0, 6) 3 (1, 8)
post_p 0.68 (0.61, 0.82) 0.63 (0.51, 0.77) 0.66 (0.53, 0.87) 0.62 (0.53, 0.82) 0.73 (0.64, 0.94) 0.82 (0.59, 0.94) 0.73 (0.57, 0.9) 0.75 (0.65, 0.93) 0.6 (0.51, 0.74) 0.59 (0.51, 0.8) 0.7 (0.54, 0.83) 0.63 (0.52, 0.9) 0.64 (0.51, 0.93) 0.76 (0.59, 0.9) 0.58 (0.52, 0.94) 0.72 (0.59, 0.86)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.1 (0.053, 0.112) 0.071 (0, 0.105) 0.088 (0.033, 0.11) 0.091 (0.043, 0.118) 0.029 (0, 0.068) 0.036 (0, 0.081) 0.039 (0, 0.079) 0.017 (0, 0.037) 0.089 (0, 0.112) 0.091 (0.023, 0.122) 0.066 (0, 0.13) 0.043 (0, 0.114) 0.023 (0, 0.078) 0.017 (0, 0.051) 0.036 (0, 0.103) 0.018 (0, 0.051)
Taxel_therapies count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 10 (5, 15) 2 (0, 4) 5 (4, 6) 3 (3, 3) 2 (1, 2) 0 (0, 0) 0 (0, 0) 2 (0, 4) 2 (1, 2) 2 (1, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (0, 2) 1 (0, 2)
post_p 0.64 (0.56, 0.73) 0.66 (0.66, 0.66) 0.67 (0.6, 0.74) 0.52 (0.52, 0.53) 0.65 (0.58, 0.72) NA (NA, NA) NA (NA, NA) 0.64 (0.64, 0.64) 0.56 (0.54, 0.57) 0.6 (0.55, 0.66) 0.57 (0.57, 0.57) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.58 (0.58, 0.58)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.013 (0.003, 0.024) 0.116 (0.116, 0.116) 0 (0, 0) 0.055 (0.011, 0.1) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0)
DRD+ Carboplatin count 322 322 322 322 322 322 322 322
time 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33)
n 7 (3, 15) 7 (3, 15) 4 (1, 9) 4 (2, 10) 4 (1, 9) 4 (2, 9) 4 (2, 9) 4 (2, 9)
post_p 0.82 (0.65, 0.98) 0.83 (0.63, 0.97) 0.74 (0.54, 0.93) 0.75 (0.55, 0.92) 0.75 (0.54, 0.93) 0.76 (0.55, 0.92) 0.74 (0.56, 0.92) 0.75 (0.54, 0.93)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.032 (0, 0.059) 0.031 (0, 0.061) 0.03 (0, 0.08) 0.032 (0, 0.069) 0.029 (0, 0.066) 0.028 (0, 0.073) 0.031 (0, 0.067) 0.03 (0, 0.084)
Niraparib count 321 321 321 321 321 321 321 321
time 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34) 21 (13, 34)
n 7 (3, 15) 6 (3, 14) 4 (1, 9) 4 (1, 9) 4 (2, 8) 4 (2, 8) 4 (1, 9) 4 (1, 9)
post_p 0.82 (0.61, 0.99) 0.85 (0.64, 0.97) 0.75 (0.57, 0.93) 0.76 (0.54, 0.93) 0.74 (0.54, 0.94) 0.74 (0.53, 0.92) 0.74 (0.54, 0.93) 0.75 (0.54, 0.93)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.03 (0, 0.062) 0.031 (0, 0.063) 0.029 (0, 0.069) 0.027 (0, 0.06) 0.028 (0, 0.073) 0.027 (0, 0.068) 0.026 (0, 0.076) 0.029 (0, 0.066)
TEfus+ Carboplatin count 24 24 24 24 24 24 24 24
time 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28)
n 4 (2, 11) 11 (6, 17) 3 (1, 7) 2 (0, 5) 4 (3, 7) 2 (1, 6) 3 (1, 4) 3 (1, 7)
post_p 0.64 (0.52, 0.79) 0.79 (0.72, 0.94) 0.7 (0.55, 0.91) 0.61 (0.53, 0.77) 0.65 (0.54, 0.78) 0.63 (0.52, 0.8) 0.66 (0.53, 0.85) 0.71 (0.58, 0.82)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.072 (0.007, 0.134) 0.068 (0.034, 0.097) 0.006 (0, 0.054) 0 (0, 0.056) 0.07 (0.012, 0.127) 0.048 (0, 0.125) 0.018 (0, 0.077) 0 (0, 0.091)
Hormone_therapies count 4 4 4 4 4 4 4 4
time 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16) 13 (9, 16)
n 5 (3, 7) 7 (4, 15) 4 (3, 5) 2 (1, 3) 3 (2, 4) 2 (1, 4) 2 (0, 5) 4 (3, 4)
post_p 0.81 (0.7, 0.86) 0.68 (0.62, 0.81) 0.58 (0.54, 0.65) 0.52 (0.51, 0.56) 0.68 (0.54, 0.87) 0.62 (0.57, 0.67) 0.64 (0.54, 0.73) 0.66 (0.55, 0.74)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.019 (0, 0.059) 0.048 (0.014, 0.083) 0.038 (0.008, 0.085) 0.075 (0.021, 0.101) 0.088 (0.061, 0.137) 0 (0, 0.069) 0.028 (0.006, 0.041) 0.045 (0.011, 0.073)
Niraparib count 24 24 24 24 24 24 24 24
time 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24) 15 (10, 24)
n 4 (1, 6) 8 (4, 17) 5 (1, 9) 3 (1, 5) 3 (2, 7) 4 (2, 7) 3 (2, 6) 2 (1, 5)
post_p 0.67 (0.54, 0.83) 0.76 (0.7, 0.89) 0.82 (0.63, 0.92) 0.68 (0.53, 0.86) 0.7 (0.56, 0.81) 0.7 (0.54, 0.78) 0.72 (0.53, 0.84) 0.65 (0.54, 0.83)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.055 (0, 0.089) 0.064 (0.035, 0.091) 0 (0, 0.039) 0 (0, 0.075) 0.077 (0, 0.11) 0.07 (0, 0.124) 0.017 (0, 0.069) 0.034 (0, 0.072)
Taxel_therapies count 2 2 2 2 2 2 2 2
time 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13)
n 6 (5, 6) 10 (9, 12) 2 (1, 4) 1 (1, 1) 4 (3, 4) 2 (0, 3) 2 (1, 2) 0 (0, 1)
post_p 0.63 (0.53, 0.73) 0.87 (0.86, 0.87) 0.83 (0.83, 0.83) 0.66 (0.65, 0.68) 0.7 (0.7, 0.71) 0.62 (0.62, 0.62) 0.62 (0.61, 0.63) 0.55 (0.55, 0.55)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.06 (0.032, 0.087) 0.061 (0.058, 0.064) 0.119 (0.119, 0.119) 0 (0, 0) 0.103 (0.061, 0.145) 0.052 (0.052, 0.052) 0.04 (0.008, 0.073) 0 (0, 0)
TP53- & AR- Carboplatin count 134 134 134 134
time 18 (9, 29) 18 (9, 29) 18 (9, 29) 18 (9, 29)
n 31 (17, 56) 5 (2, 12) 5 (2, 13) 5 (2, 13)
post_p 0.77 (0.71, 0.92) 0.71 (0.53, 0.87) 0.78 (0.58, 0.94) 0.78 (0.58, 0.96)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.088 (0.061, 0.115) 0.07 (0, 0.118) 0.031 (0, 0.057) 0.031 (0, 0.061)
Hormone_therapies count 9 9 9 9
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 18 (16, 25) 4 (3, 5) 4 (2, 5) 4 (2, 10)
post_p 0.82 (0.8, 0.9) 0.6 (0.51, 0.77) 0.67 (0.53, 0.71) 0.63 (0.54, 0.84)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.079 (0.051, 0.098) 0.058 (0, 0.108) 0.042 (0, 0.114) 0.029 (0, 0.062)
Niraparib count 151 151 151 151
time 15 (9, 30) 15 (9, 30) 15 (9, 30) 15 (9, 30)
n 27 (16, 55) 4 (1, 12) 5 (2, 12) 5 (2, 10)
post_p 0.76 (0.71, 0.9) 0.7 (0.53, 0.84) 0.8 (0.58, 0.95) 0.78 (0.6, 0.95)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.088 (0.054, 0.11) 0.073 (0, 0.104) 0.025 (0, 0.056) 0.025 (0, 0.059)
Taxel_therapies count 11 11 11 11
time 12 (10, 19) 12 (10, 19) 12 (10, 19) 12 (10, 19)
n 19 (14, 30) 3 (2, 6) 3 (2, 5) 4 (3, 5)
post_p 0.8 (0.74, 0.9) 0.69 (0.51, 0.84) 0.64 (0.53, 0.76) 0.68 (0.56, 0.77)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.087 (0.067, 0.098) 0.048 (0, 0.173) 0 (0, 0.076) 0.053 (0, 0.119)
TP53+ Carboplatin count 25 25 25 25 25 25 25 25
time 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27) 18 (9, 27)
n 14 (7, 29) 10 (4, 18) 3 (1, 7) 3 (0, 8) 4 (0, 7) 4 (1, 8) 3 (0, 6) 2 (1, 5)
post_p 0.76 (0.73, 0.88) 0.75 (0.6, 0.85) 0.73 (0.56, 0.92) 0.76 (0.59, 0.93) 0.64 (0.51, 0.77) 0.74 (0.54, 0.86) 0.68 (0.52, 0.91) 0.66 (0.54, 0.9)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.077 (0.033, 0.111) 0.074 (0.014, 0.099) 0.018 (0, 0.072) 0.025 (0, 0.046) 0.077 (0, 0.145) 0.06 (0, 0.107) 0.009 (0, 0.061) 0 (0, 0.091)
Hormone_therapies count 6 6 6 6 6 6 6 6
time 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9) 8 (7, 9)
n 12 (9, 12) 6 (3, 8) 2 (0, 3) 1 (0, 2) 4 (3, 5) 2 (0, 2) 2 (1, 3) 0 (0, 2)
post_p 0.82 (0.77, 0.88) 0.72 (0.64, 0.86) 0.53 (0.51, 0.55) 0.65 (0.62, 0.68) 0.7 (0.67, 0.83) 0.54 (0.54, 0.6) 0.52 (0.51, 0.59) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.042 (0.029, 0.071) 0.022 (0, 0.091) 0 (0, 0) 0 (0, 0) 0.061 (0, 0.155) 0.064 (0, 0.144) 0.08 (0, 0.225) 0 (0, 0.506)
Niraparib count 27 27 27 27 27 27 27 27
time 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29) 16 (10, 29)
n 19 (8, 32) 11 (5, 21) 3 (1, 7) 3 (1, 6) 5 (1, 9) 4 (2, 7) 3 (1, 4) 2 (1, 5)
post_p 0.78 (0.71, 0.88) 0.78 (0.71, 0.87) 0.77 (0.62, 0.94) 0.69 (0.54, 0.84) 0.71 (0.56, 0.87) 0.69 (0.53, 0.83) 0.63 (0.52, 0.81) 0.67 (0.52, 0.91)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.073 (0.032, 0.104) 0.079 (0.036, 0.097) 0.016 (0, 0.048) 0 (0, 0.048) 0.059 (0, 0.105) 0.07 (0, 0.116) 0.016 (0, 0.085) 0 (0, 0.057)
Taxel_therapies count 5 5 5 5 5 5 5 5
time 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11) 10 (9, 11)
n 10 (9, 15) 7 (6, 9) 1 (0, 3) 2 (1, 4) 3 (1, 4) 1 (0, 3) 1 (1, 3) 3 (0, 4)
post_p 0.79 (0.74, 0.85) 0.72 (0.68, 0.76) 0.53 (0.52, 0.86) 0.55 (0.52, 0.71) 0.77 (0.67, 0.82) 0.84 (0.62, 0.88) 0.58 (0.53, 0.61) 0.55 (0.53, 0.7)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.047 (0.034, 0.053) 0.055 (0.05, 0.085) 0.028 (0.006, 0.127) 0.061 (0, 0.131) 0 (0, 0.042) 0 (0, 0) 0 (0, 0.05) 0.068 (0.051, 0.115)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 6 (6, 6) 1 (1, 1) 6 (6, 6) 3 (3, 3) 0 (0, 0) 1 (1, 1) 0 (0, 0) 2 (2, 2) 3 (3, 3) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 4 (4, 4) 1 (1, 1) 2 (2, 2)
post_p 0.05 (0.05, 0.05) 0.48 (0.48, 0.48) 0.19 (0.19, 0.19) 0.47 (0.47, 0.47) NA (NA, NA) 0.22 (0.22, 0.22) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) 0.45 (0.45, 0.45) NA (NA, NA) 0.43 (0.43, 0.43)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.257 (0.257, 0.257) 0 (0, 0) 0.211 (0.211, 0.211) 0.141 (0.141, 0.141) NA (NA, NA) 0.955 (0.955, 0.955) NA (NA, NA) 0 (0, 0) 0.141 (0.141, 0.141) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Hormone_therapies count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
time 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25) 13 (6, 25)
n 19 (12, 28) 4 (2, 6) 8 (4, 26) 5 (4, 13) 3 (2, 6) 2 (0, 8) 1 (0, 4) 2 (0, 7) 3 (2, 6) 4 (0, 6) 4 (1, 9) 2 (0, 8) 2 (0, 7) 2 (0, 5) 2 (0, 6) 3 (0, 4)
post_p 0.33 (0.05, 0.44) 0.39 (0.31, 0.45) 0.38 (0.24, 0.46) 0.41 (0.31, 0.49) 0.41 (0.27, 0.44) 0.39 (0.16, 0.41) 0.42 (0.19, 0.47) 0.39 (0.32, 0.45) 0.41 (0.29, 0.48) 0.38 (0.27, 0.42) 0.36 (0.1, 0.45) 0.4 (0.34, 0.46) 0.31 (0.23, 0.43) 0.37 (0.24, 0.44) 0.29 (0.24, 0.43) 0.3 (0.24, 0.37)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.124 (0.096, 0.181) 0.137 (0.085, 0.167) 0.149 (0.115, 0.295) 0.128 (0.071, 0.207) 0.118 (0.086, 0.131) 0.164 (0.1, 0.511) 0.129 (0.033, 0.242) 0.112 (0.067, 0.846) 0.18 (0.118, 0.389) 0.142 (0.037, 0.299) 0.168 (0.114, 0.411) 0.134 (0.107, 0.331) 0.163 (0.092, 0.888) 0.146 (0.117, 0.212) 0.204 (0.105, 0.245) 0.118 (0.11, 0.151)
Taxel_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28) 14 (4, 28)
n 22 (6, 54) 6 (3, 10) 12 (5, 22) 8 (3, 14) 4 (2, 7) 2 (0, 6) 1 (0, 1) 2 (1, 4) 4 (1, 7) 2 (0, 4) 2 (0, 5) 2 (0, 3) 4 (1, 6) 2 (2, 3) 4 (1, 8) 1 (0, 5)
post_p 0.35 (0.16, 0.46) 0.36 (0.32, 0.44) 0.37 (0.26, 0.47) 0.33 (0.2, 0.46) 0.28 (0.22, 0.39) 0.35 (0.33, 0.36) 0.41 (0.3, 0.48) 0.34 (0.17, 0.42) 0.24 (0.21, 0.41) 0.27 (0.14, 0.38) 0.28 (0.25, 0.39) 0.32 (0.26, 0.36) 0.42 (0.17, 0.45) 0.25 (0.14, 0.4) 0.37 (0.22, 0.43) 0.24 (0.16, 0.32)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.14 (0.106, 0.2) 0.133 (0.097, 0.185) 0.18 (0.128, 0.262) 0.128 (0.112, 0.151) 0.143 (0.113, 0.32) 0.173 (0.123, 3.05) 0.174 (0.035, 1.541) 0.224 (0.027, 0.437) 0.306 (0.262, 0.433) 0.628 (0.361, 1.226) 0.184 (0.136, 0.58) 0.225 (0.162, 0.746) 0.263 (0.138, 0.841) 0.297 (0.02, 0.554) 0.136 (0.118, 0.202) 0.183 (0.165, 0.202)
DRD+ Hormone_therapies count 173 173 173 173 173 173 173 173
time 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33) 23 (13, 33)
n 7 (3, 14) 7 (3, 13) 5 (2, 9) 4 (1, 9) 5 (2, 9) 4 (2, 8) 4 (1, 8) 5 (1, 9)
post_p 0.28 (0.11, 0.47) 0.28 (0.09, 0.45) 0.3 (0.11, 0.47) 0.31 (0.13, 0.46) 0.33 (0.13, 0.47) 0.33 (0.12, 0.45) 0.33 (0.14, 0.47) 0.35 (0.14, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.131 (0.086, 0.231) 0.139 (0.089, 0.27) 0.136 (0.079, 0.307) 0.144 (0.08, 0.346) 0.125 (0.074, 0.293) 0.133 (0.071, 0.289) 0.127 (0.07, 0.303) 0.14 (0.085, 0.308)
Taxel_therapies count 160 160 160 160 160 160 160 160
time 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34) 23 (15, 34)
n 6 (2, 14) 6 (3, 13) 5 (2, 9) 4 (2, 9) 5 (2, 9) 5 (2, 10) 5 (2, 9) 5 (1, 9)
post_p 0.3 (0.11, 0.46) 0.3 (0.09, 0.46) 0.34 (0.19, 0.47) 0.3 (0.14, 0.47) 0.34 (0.13, 0.47) 0.32 (0.11, 0.47) 0.32 (0.11, 0.47) 0.3 (0.14, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.079, 0.354) 0.132 (0.086, 0.252) 0.124 (0.081, 0.277) 0.129 (0.077, 0.289) 0.128 (0.076, 0.341) 0.137 (0.082, 0.334) 0.133 (0.076, 0.313) 0.14 (0.084, 0.366)
TEfus+ Carboplatin count 1 1 1 1 1 1 1 1
time 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18)
n 11 (11, 11) 14 (14, 14) 12 (12, 12) 2 (2, 2) 2 (2, 2) 2 (2, 2) 3 (3, 3) 1 (1, 1)
post_p 0.24 (0.24, 0.24) 0.19 (0.19, 0.19) 0.4 (0.4, 0.4) 0.5 (0.5, 0.5) 0.43 (0.43, 0.43) 0.16 (0.16, 0.16) 0.4 (0.4, 0.4) 0.35 (0.35, 0.35)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.14 (0.14, 0.14) 0.143 (0.143, 0.143) 0.06 (0.06, 0.06) 0.074 (0.074, 0.074) 0.147 (0.147, 0.147) 0.282 (0.282, 0.282) 0.073 (0.073, 0.073) 0.807 (0.807, 0.807)
Hormone_therapies count 64 64 64 64 64 64 64 64
time 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33) 15 (11, 33)
n 5 (3, 11) 10 (6, 23) 5 (2, 10) 3 (1, 8) 4 (2, 8) 4 (1, 9) 3 (1, 7) 3 (1, 7)
post_p 0.39 (0.13, 0.48) 0.31 (0.13, 0.47) 0.26 (0.09, 0.44) 0.34 (0.13, 0.46) 0.37 (0.17, 0.48) 0.3 (0.09, 0.46) 0.34 (0.19, 0.46) 0.33 (0.19, 0.46)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.145 (0.094, 0.267) 0.146 (0.099, 0.241) 0.157 (0.089, 0.296) 0.154 (0.062, 0.589) 0.165 (0.101, 0.466) 0.177 (0.103, 0.417) 0.146 (0.061, 0.38) 0.145 (0.082, 0.335)
Niraparib count 2 2 2 2 2 2 2 2
time 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10)
n 3 (3, 3) 10 (8, 12) 3 (2, 4) 0 (0, 0) 4 (2, 5) 2 (1, 3) 3 (2, 4) 1 (0, 2)
post_p 0.4 (0.34, 0.46) 0.29 (0.23, 0.34) 0.35 (0.26, 0.45) NA (NA, NA) 0.28 (0.23, 0.33) 0.41 (0.36, 0.46) 0.25 (0.1, 0.4) 0.47 (0.47, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.125 (0.084, 0.166) 0.123 (0.101, 0.146) 0.123 (0.076, 0.17) NA (NA, NA) 0.344 (0.286, 0.401) 1.454 (0.364, 2.543) 0.267 (0.224, 0.31) 0 (0, 0)
Taxel_therapies count 45 45 45 45 45 45 45 45
time 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30) 20 (12, 30)
n 7 (2, 12) 12 (6, 22) 5 (2, 14) 4 (0, 7) 5 (2, 12) 5 (2, 9) 4 (2, 8) 4 (2, 8)
post_p 0.4 (0.18, 0.48) 0.37 (0.19, 0.48) 0.31 (0.13, 0.42) 0.35 (0.24, 0.45) 0.32 (0.14, 0.47) 0.38 (0.18, 0.49) 0.32 (0.2, 0.45) 0.34 (0.14, 0.47)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.139 (0.09, 0.283) 0.131 (0.107, 0.185) 0.127 (0.077, 0.364) 0.13 (0.081, 0.367) 0.164 (0.104, 0.431) 0.182 (0.106, 0.264) 0.136 (0.083, 0.386) 0.141 (0.097, 0.313)
TP53- & AR- Carboplatin count 9 9 9 9
time 10 (9, 14) 10 (9, 14) 10 (9, 14) 10 (9, 14)
n 17 (14, 23) 4 (2, 7) 4 (3, 5) 4 (0, 6)
post_p 0.22 (0.13, 0.35) 0.35 (0.21, 0.44) 0.43 (0.26, 0.47) 0.44 (0.23, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.141 (0.12, 0.183) 0.137 (0.081, 0.524) 0.102 (0.053, 0.146) 0.11 (0.054, 0.204)
Hormone_therapies count 203 203 203 203
time 17 (10, 30) 17 (10, 30) 17 (10, 30) 17 (10, 30)
n 26 (15, 56) 6 (2, 11) 6 (3, 12) 5 (2, 11)
post_p 0.3 (0.11, 0.46) 0.39 (0.15, 0.48) 0.34 (0.09, 0.48) 0.31 (0.12, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.102, 0.172) 0.145 (0.096, 0.325) 0.128 (0.079, 0.266) 0.14 (0.085, 0.305)
Niraparib count 6 6 6 6
time 11 (10, 18) 11 (10, 18) 11 (10, 18) 11 (10, 18)
n 20 (18, 26) 3 (1, 8) 3 (1, 5) 4 (1, 7)
post_p 0.34 (0.12, 0.48) 0.3 (0.17, 0.42) 0.41 (0.33, 0.47) 0.45 (0.34, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.118 (0.095, 0.162) 0.302 (0.097, 0.358) 0.112 (0.101, 0.801) 0.122 (0.035, 0.172)
Taxel_therapies count 216 216 216 216
time 17 (10, 31) 17 (10, 31) 17 (10, 31) 17 (10, 31)
n 28 (16, 56) 6 (2, 13) 5 (2, 12) 6 (3, 13)
post_p 0.32 (0.09, 0.47) 0.36 (0.12, 0.48) 0.33 (0.11, 0.47) 0.31 (0.1, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.127 (0.104, 0.179) 0.152 (0.095, 0.336) 0.133 (0.079, 0.327) 0.13 (0.081, 0.338)
TP53+ Carboplatin count 2 2 2 2 2 2 2 2
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 10 (8, 13) 6 (4, 9) 2 (1, 2) 2 (0, 4) 4 (2, 5) 3 (1, 5) 2 (0, 3) 0 (0, 0)
post_p 0.35 (0.23, 0.47) 0.33 (0.25, 0.41) 0.4 (0.32, 0.48) 0.46 (0.46, 0.46) 0.39 (0.34, 0.44) 0.31 (0.24, 0.38) 0.28 (0.28, 0.28) NA (NA, NA)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.131 (0.116, 0.146) 0.156 (0.136, 0.176) 14.383 (2.877, 25.889) 0.07 (0.07, 0.07) 0.132 (0.131, 0.133) 0.248 (0.14, 0.356) 0.131 (0.131, 0.131) NA (NA, NA)
Hormone_therapies count 75 75 75 75 75 75 75 75
time 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30) 18 (9, 30)
n 15 (9, 32) 10 (4, 24) 4 (0, 8) 3 (1, 8) 5 (1, 11) 4 (1, 8) 4 (1, 8) 3 (1, 9)
post_p 0.33 (0.11, 0.48) 0.35 (0.17, 0.49) 0.33 (0.14, 0.46) 0.33 (0.15, 0.44) 0.35 (0.16, 0.48) 0.36 (0.15, 0.49) 0.33 (0.18, 0.48) 0.35 (0.12, 0.46)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.133 (0.105, 0.198) 0.135 (0.107, 0.23) 0.131 (0.079, 0.334) 0.151 (0.069, 0.417) 0.156 (0.091, 0.35) 0.174 (0.102, 0.352) 0.125 (0.048, 0.316) 0.14 (0.088, 0.344)
Niraparib count 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 4 (4, 4) 9 (9, 9) 2 (2, 2) 3 (3, 3) 5 (5, 5) 3 (3, 3) 1 (1, 1) 1 (1, 1)
post_p 0.25 (0.25, 0.25) 0.28 (0.28, 0.28) NA (NA, NA) 0.48 (0.48, 0.48) 0.34 (0.34, 0.34) 0.44 (0.44, 0.44) 0.46 (0.46, 0.46) 0.41 (0.41, 0.41)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.287 (0.287, 0.287) 0.176 (0.176, 0.176) 0 (0, 0) 0 (0, 0) 0.106 (0.106, 0.106) 0.155 (0.155, 0.155) 0 (0, 0) 0.257 (0.257, 0.257)
Taxel_therapies count 49 49 49 49 49 49 49 49
time 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32)
n 18 (8, 29) 13 (5, 22) 4 (1, 8) 4 (1, 7) 4 (1, 10) 5 (1, 10) 5 (0, 9) 4 (1, 9)
post_p 0.29 (0.12, 0.47) 0.36 (0.15, 0.48) 0.33 (0.16, 0.45) 0.35 (0.2, 0.47) 0.34 (0.18, 0.45) 0.39 (0.14, 0.48) 0.34 (0.15, 0.48) 0.31 (0.18, 0.46)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.138 (0.11, 0.181) 0.14 (0.108, 0.25) 0.115 (0.063, 0.317) 0.125 (0.081, 0.379) 0.161 (0.11, 0.373) 0.167 (0.088, 0.383) 0.129 (0.06, 0.339) 0.151 (0.097, 0.579)