Simulation scenario 9

Setting description

Equal randomization: Carboplatin more effective in the DRD+ biomarker signature (cfr scen 6)

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.075, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 13.1, median = 9.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1.49, hr = 0.66

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 4 2 13 19 TP53- & AR- 9 11 134 151 TP53+ 6 5 25 27 DRD+ 0 0 322 321 TEfus+ 4 2 24 24

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.008 0.004 0.026 0.038 TP53- & AR- 0.018 0.022 0.268 0.302 TP53+ 0.012 0.010 0.050 0.054 DRD+ 0.000 0.000 0.644 0.642 TEfus+ 0.008 0.004 0.048 0.048

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 6 4 1 0 TP53- & AR- 203 216 9 6 TP53+ 75 49 2 1 DRD+ 173 160 0 0 TEfus+ 64 45 1 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.012 0.008 0.002 0.000 TP53- & AR- 0.406 0.432 0.018 0.012 TP53+ 0.150 0.098 0.004 0.002 DRD+ 0.346 0.320 0.000 0.000 TEfus+ 0.128 0.090 0.002 0.004

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 7 6 6 15 TP53+ 7 17 4 9 DRD+ 0 0 0 0 TEfus+ 1 0 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.014 0.012 0.012 0.030 TP53+ 0.014 0.034 0.008 0.018 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.002 0.000 0.000 0.000

Errors & power

The overall error was 0.276.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.044             0.036             0.126             0.110 

The overall power was 0.872.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.000             0.644             0.642 

Median results at the end of the trial

By signature:

signature	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
all	graduation	13	0	4	19	2
	futility	1	0	6	0	4
	max_n	0	0	0	0	0
	n	227 (164, 275)	278 (246, 321)	217 (145, 280)	224 (155, 282)	225 (157, 286)
	n_unique	209 (152, 255)	254 (226, 292)	200 (134, 260)	204 (143, 260)	208 (143, 266)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	12 (5, 28)	NA (NA, NA)	6 (4, 21)	22 (5, 34)	4 (4, 26)
	post_p	1 (0.94, 1)	NA (NA, NA)	0.42 (0.08, 0.85)	1 (0.94, 1)	0.46 (0.1, 0.9)
	rate	0.083 (0.073, 0.093)	0.113 (0.102, 0.122)	0.113 (0.103, 0.126)	0.082 (0.072, 0.093)	0.112 (0.101, 0.124)
DRD+	graduation	322	0	0	321	0
	futility	0	0	173	0	160
	max_n	0	0	0	0	0
	n	53 (26, 85)	85 (67, 107)	62 (29, 91)	53 (26, 87)	66 (31, 98)
	n_unique	47 (23, 76)	78 (61, 100)	56 (26, 84)	47 (24, 80)	60 (28, 90)
	time_trial	30 (15, 36)	36 (36, 36)	36 (19, 36)	29 (15, 36)	36 (19, 36)
	time_stop	22 (14, 33)	NA (NA, NA)	23 (13, 33)	21 (13, 34)	23 (15, 34)
	post_p	1 (1, 1)	NA (NA, NA)	0.27 (0.05, 0.73)	1 (1, 1)	0.3 (0.03, 0.7)
	rate	0.036 (0.028, 0.046)	0.113 (0.097, 0.131)	0.115 (0.093, 0.141)	0.036 (0.026, 0.045)	0.113 (0.094, 0.141)
TEfus+	graduation	24	0	4	24	2
	futility	1	0	64	2	45
	max_n	0	0	1	0	0
	n	81 (57, 107)	105 (88, 126)	81 (39, 108)	82 (56, 108)	87 (53, 112)
	n_unique	74 (52, 98)	96 (80, 116)	75 (36, 98)	75 (49, 98)	80 (49, 103)
	time_trial	36 (36, 36)	36 (36, 36)	36 (25, 36)	36 (36, 36)	36 (36, 36)
	time_stop	15 (10, 27)	NA (NA, NA)	15 (11, 32)	14 (10, 24)	20 (12, 30)
	post_p	0.99 (0.86, 1)	NA (NA, NA)	0.41 (0.06, 0.82)	0.99 (0.83, 1)	0.42 (0.09, 0.86)
	rate	0.074 (0.061, 0.089)	0.112 (0.099, 0.13)	0.114 (0.096, 0.139)	0.074 (0.06, 0.089)	0.112 (0.095, 0.133)
TP53- & AR-	graduation	134	0	9	151	11
	futility	9	0	203	6	216
	max_n	6	0	7	15	6
	n	95 (31, 126)	119 (97, 144)	88 (28, 123)	92 (29, 129)	90 (28, 126)
	n_unique	88 (29, 117)	109 (89, 133)	83 (27, 115)	86 (26, 120)	85 (26, 119)
	time_trial	36 (14, 36)	36 (36, 36)	36 (12, 36)	36 (12, 36)	36 (12, 36)
	time_stop	17 (9, 29)	NA (NA, NA)	16 (10, 30)	15 (9, 29)	17 (10, 31)
	post_p	0.95 (0.62, 1)	NA (NA, NA)	0.41 (0.09, 0.84)	0.96 (0.61, 1)	0.41 (0.08, 0.84)
	rate	0.085 (0.07, 0.104)	0.113 (0.099, 0.128)	0.114 (0.097, 0.14)	0.084 (0.067, 0.102)	0.114 (0.097, 0.143)
TP53+	graduation	25	0	6	27	5
	futility	2	0	75	1	49
	max_n	4	0	7	9	17
	n	103 (77, 124)	120 (102, 144)	104 (47, 127)	103 (78, 129)	108 (70, 133)
	n_unique	95 (70, 115)	109 (93, 130)	95 (43, 117)	95 (71, 118)	100 (63, 124)
	time_trial	36 (36, 36)	36 (36, 36)	36 (21, 36)	36 (36, 36)	36 (34, 36)
	time_stop	17 (10, 26)	NA (NA, NA)	17 (9, 30)	16 (9, 29)	18 (9, 31)
	post_p	0.96 (0.74, 1)	NA (NA, NA)	0.4 (0.1, 0.81)	0.96 (0.7, 1)	0.46 (0.11, 0.86)
	rate	0.084 (0.071, 0.098)	0.113 (0.099, 0.128)	0.114 (0.1, 0.135)	0.084 (0.07, 0.099)	0.113 (0.098, 0.13)

By subgroup combinations:

subtype	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
—-	graduation	152	0	218	165	231
	futility	0	0	0	0	0
	max_n	6	0	7	15	6
	n	62 (21, 83)	71 (55, 92)	56 (17, 75)	60 (19, 82)	54 (18, 78)
	n_unique	58 (19, 78)	65 (51, 85)	53 (16, 72)	56 (17, 77)	52 (17, 73)
	post_p	0.54 (0.14, 0.88)	NA (NA, NA)	0.49 (0.11, 0.88)	0.55 (0.11, 0.86)	0.46 (0.1, 0.87)
	rate	0.112 (0.093, 0.134)	0.113 (0.094, 0.134)	0.113 (0.094, 0.144)	0.112 (0.092, 0.135)	0.115 (0.093, 0.147)
—+	graduation	165	0	241	178	248
	futility	0	0	0	0	0
	max_n	6	0	8	15	6
	n	12 (3, 19)	15 (10, 22)	10 (3, 17)	12 (3, 19)	10 (3, 19)
	n_unique	11 (3, 18)	14 (8, 20)	9 (3, 16)	10 (3, 17)	9 (3, 17)
	post_p	0.52 (0.18, 0.84)	NA (NA, NA)	0.5 (0.18, 0.82)	0.52 (0.19, 0.82)	0.47 (0.18, 0.84)
	rate	0.11 (0.072, 0.17)	0.115 (0.078, 0.172)	0.117 (0.078, 0.212)	0.112 (0.07, 0.17)	0.117 (0.079, 0.22)
–+-	graduation	40	0	88	44	58
	futility	0	0	0	0	0
	max_n	4	0	7	9	17
	n	35 (26, 45)	37 (29, 47)	34 (15, 44)	36 (25, 45)	35 (23, 44)
	n_unique	33 (24, 42)	34 (26, 44)	32 (15, 41)	33 (23, 42)	32 (21, 42)
	post_p	0.53 (0.16, 0.88)	NA (NA, NA)	0.5 (0.13, 0.85)	0.49 (0.14, 0.87)	0.52 (0.16, 0.88)
	rate	0.113 (0.088, 0.143)	0.114 (0.089, 0.143)	0.115 (0.09, 0.153)	0.115 (0.087, 0.145)	0.113 (0.089, 0.146)
–++	graduation	59	0	139	63	92
	futility	0	0	0	0	0
	max_n	4	0	7	9	17
	n	24 (15, 32)	25 (19, 35)	22 (8, 31)	24 (14, 32)	23 (12, 32)
	n_unique	22 (14, 30)	23 (16, 32)	21 (7, 28)	22 (13, 30)	21 (11, 29)
	post_p	0.5 (0.15, 0.86)	NA (NA, NA)	0.47 (0.15, 0.84)	0.53 (0.14, 0.84)	0.51 (0.16, 0.86)
	rate	0.113 (0.083, 0.152)	0.113 (0.084, 0.152)	0.118 (0.084, 0.167)	0.112 (0.083, 0.151)	0.112 (0.086, 0.156)
-+–	graduation	378	0	302	373	299
	futility	0	0	0	0	0
	max_n	6	0	7	12	6
	n	9 (3, 17)	16 (9, 23)	10 (3, 20)	9 (3, 17)	10 (3, 19)
	n_unique	8 (3, 16)	14 (9, 21)	9 (3, 18)	8 (3, 16)	9 (3, 18)
	post_p	0.94 (0.75, 0.99)	NA (NA, NA)	0.3 (0.09, 0.66)	0.94 (0.71, 1)	0.31 (0.08, 0.62)
	rate	0.036 (0.017, 0.063)	0.114 (0.079, 0.168)	0.119 (0.077, 0.206)	0.036 (0.015, 0.067)	0.119 (0.078, 0.227)
-+-+	graduation	383	0	316	376	309
	futility	0	0	0	0	0
	max_n	6	0	8	12	6
	n	9 (3, 17)	16 (10, 23)	9 (3, 20)	8 (3, 18)	10 (3, 20)
	n_unique	8 (2, 16)	15 (9, 22)	8 (2, 18)	8 (3, 16)	9 (3, 18)
	post_p	0.93 (0.71, 0.99)	NA (NA, NA)	0.31 (0.08, 0.63)	0.94 (0.72, 1)	0.3 (0.1, 0.65)
	rate	0.037 (0.016, 0.066)	0.111 (0.078, 0.166)	0.121 (0.076, 0.222)	0.036 (0.016, 0.062)	0.117 (0.076, 0.211)
-++-	graduation	340	0	232	328	193
	futility	0	0	0	0	0
	max_n	2	0	6	9	17
	n	5 (2, 10)	9 (5, 13)	7 (2, 12)	6 (2, 11)	7 (3, 13)
	n_unique	5 (1, 9)	8 (4, 12)	6 (2, 11)	5 (2, 11)	6 (2, 12)
	post_p	0.84 (0.59, 0.97)	NA (NA, NA)	0.32 (0.11, 0.63)	0.87 (0.59, 0.98)	0.32 (0.11, 0.64)
	rate	0.037 (0.014, 0.085)	0.118 (0.072, 0.192)	0.123 (0.072, 0.242)	0.034 (0.014, 0.072)	0.119 (0.072, 0.217)
-+++	graduation	346	0	259	334	210
	futility	0	0	0	0	0
	max_n	2	0	6	9	17
	n	5 (2, 11)	9 (5, 13)	6 (1, 11)	6 (2, 11)	7 (2, 13)
	n_unique	5 (2, 10)	8 (4, 12)	6 (1, 10)	5 (2, 10)	6 (2, 12)
	post_p	0.86 (0.59, 0.97)	NA (NA, NA)	0.33 (0.12, 0.63)	0.85 (0.59, 0.98)	0.34 (0.1, 0.62)
	rate	0.035 (0.015, 0.073)	0.115 (0.07, 0.194)	0.121 (0.069, 0.256)	0.034 (0.013, 0.072)	0.118 (0.065, 0.219)
+—	graduation	14	0	10	19	6
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	12 (7, 17)	12 (8, 17)	12 (8, 17)	12 (7, 17)	12 (8, 17)
	n_unique	11 (6, 16)	11 (7, 16)	11 (6, 16)	11 (6, 16)	11 (7, 16)
	post_p	0.48 (0.16, 0.86)	NA (NA, NA)	0.49 (0.18, 0.82)	0.5 (0.15, 0.81)	0.52 (0.18, 0.85)
	rate	0.116 (0.072, 0.182)	0.114 (0.073, 0.171)	0.115 (0.075, 0.176)	0.116 (0.076, 0.182)	0.113 (0.074, 0.177)
+–+	graduation	38	0	76	43	51
	futility	0	0	0	0	0
	max_n	0	0	1	0	0
	n	9 (5, 14)	10 (6, 14)	9 (4, 14)	9 (5, 14)	9 (5, 14)
	n_unique	8 (5, 13)	9 (5, 13)	8 (4, 13)	8 (4, 13)	8 (4, 13)
	post_p	0.5 (0.18, 0.81)	NA (NA, NA)	0.48 (0.19, 0.8)	0.5 (0.17, 0.83)	0.51 (0.18, 0.85)
	rate	0.113 (0.071, 0.192)	0.115 (0.071, 0.186)	0.117 (0.077, 0.202)	0.115 (0.069, 0.185)	0.112 (0.068, 0.193)
+-+-	graduation	40	0	88	44	58
	futility	0	0	0	0	0
	max_n	4	0	7	9	17
	n	10 (5, 14)	10 (6, 14)	9 (4, 13)	10 (5, 14)	9 (5, 14)
	n_unique	9 (5, 13)	9 (5, 13)	8 (4, 12)	9 (5, 13)	9 (4, 13)
	post_p	0.5 (0.18, 0.82)	NA (NA, NA)	0.48 (0.15, 0.78)	0.52 (0.17, 0.81)	0.5 (0.18, 0.82)
	rate	0.112 (0.068, 0.201)	0.11 (0.069, 0.179)	0.118 (0.073, 0.215)	0.116 (0.07, 0.184)	0.115 (0.071, 0.19)
+-++	graduation	59	0	139	63	92
	futility	0	0	0	0	0
	max_n	4	0	7	9	17
	n	9 (4, 15)	10 (6, 16)	9 (3, 14)	10 (4, 14)	9 (4, 15)
	n_unique	8 (4, 13)	10 (6, 15)	8 (2, 13)	8 (4, 13)	9 (3, 14)
	post_p	0.5 (0.19, 0.82)	NA (NA, NA)	0.48 (0.17, 0.82)	0.51 (0.18, 0.82)	0.53 (0.16, 0.83)
	rate	0.115 (0.066, 0.197)	0.114 (0.075, 0.183)	0.121 (0.073, 0.212)	0.113 (0.066, 0.192)	0.112 (0.069, 0.204)
++–	graduation	331	0	182	327	164
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	5 (2, 11)	9 (5, 13)	7 (2, 12)	6 (2, 11)	7 (3, 12)
	n_unique	5 (2, 10)	8 (4, 12)	6 (2, 11)	5 (2, 9)	7 (2, 11)
	post_p	0.84 (0.55, 0.97)	NA (NA, NA)	0.34 (0.1, 0.62)	0.85 (0.55, 0.97)	0.34 (0.11, 0.62)
	rate	0.039 (0.012, 0.079)	0.117 (0.07, 0.191)	0.118 (0.07, 0.232)	0.039 (0.011, 0.078)	0.118 (0.067, 0.223)
++-+	graduation	339	0	216	334	186
	futility	0	0	0	0	0
	max_n	0	0	1	0	0
	n	5 (2, 11)	9 (5, 13)	7 (2, 12)	5 (2, 11)	7 (3, 12)
	n_unique	5 (2, 10)	8 (4, 12)	6 (2, 11)	5 (2, 9)	7 (3, 12)
	post_p	0.85 (0.56, 0.98)	NA (NA, NA)	0.34 (0.12, 0.63)	0.85 (0.58, 0.97)	0.34 (0.12, 0.65)
	rate	0.037 (0.013, 0.077)	0.116 (0.071, 0.206)	0.121 (0.067, 0.232)	0.037 (0.014, 0.082)	0.116 (0.064, 0.199)
+++-	graduation	340	0	232	328	193
	futility	0	0	0	0	0
	max_n	2	0	6	9	17
	n	5 (2, 10)	9 (5, 14)	6 (2, 11)	5 (2, 11)	7 (2, 11)
	n_unique	4 (2, 9)	8 (4, 13)	6 (2, 10)	5 (1, 10)	6 (2, 11)
	post_p	0.83 (0.56, 0.97)	NA (NA, NA)	0.35 (0.13, 0.65)	0.86 (0.55, 0.97)	0.33 (0.11, 0.66)
	rate	0.036 (0.014, 0.079)	0.119 (0.068, 0.197)	0.12 (0.064, 0.228)	0.036 (0.012, 0.077)	0.116 (0.067, 0.215)
++++	graduation	346	0	259	334	210
	futility	0	0	0	0	0
	max_n	2	0	6	9	17
	n	5 (2, 10)	9 (5, 14)	6 (2, 13)	5 (2, 11)	7 (2, 12)
	n_unique	5 (1, 9)	8 (5, 13)	6 (1, 11)	5 (1, 10)	6 (2, 11)
	post_p	0.85 (0.52, 0.98)	NA (NA, NA)	0.34 (0.12, 0.64)	0.85 (0.59, 0.97)	0.32 (0.11, 0.62)
	rate	0.038 (0.012, 0.085)	0.114 (0.067, 0.209)	0.122 (0.068, 0.242)	0.038 (0.013, 0.077)	0.121 (0.07, 0.248)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	4	2	13	19
	time_stop	4 (4, 5)	4 (4, 4)	15 (6, 28)	22 (5, 34)
	n_trt	26 (25, 28)	29 (28, 30)	87 (36, 178)	107 (31, 182)
	n_control	26 (18, 31)	25 (23, 27)	102 (40, 214)	156 (30, 254)
	post_p	0.89 (0.85, 0.92)	0.91 (0.88, 0.93)	0.99 (0.96, 1)	1 (0.97, 1)
	order	1 (1, 1)	1 (1, 1)	1 (1, 3.8)	3 (1, 4)
TP53- & AR-	count	9	11	134	151
	time_stop	12 (10, 14)	12 (10, 19)	18 (9, 29)	15 (9, 30)
	n_trt	33 (27, 38)	27 (25, 43)	48 (26, 92)	40 (26, 86)
	n_control	32 (25, 43)	36 (26, 57)	51 (22, 90)	44 (24, 91)
	post_p	0.93 (0.88, 0.97)	0.93 (0.86, 0.97)	0.96 (0.9, 1)	0.97 (0.9, 1)
	order	1 (1, 2)	2 (1, 3)	2 (1, 3)	1 (1, 3)
TP53+	count	6	5	25	27
	time_stop	8 (7, 9)	10 (9, 11)	18 (9, 27)	16 (10, 29)
	n_trt	26 (25, 29)	30 (27, 33)	46 (25, 78)	48 (27, 86)
	n_control	20 (20, 26)	35 (28, 38)	57 (23, 93)	52 (27, 96)
	post_p	0.93 (0.9, 0.97)	0.96 (0.94, 0.97)	0.99 (0.94, 1)	0.98 (0.96, 1)
	order	1 (1, 1)	2 (1, 2)	2 (1, 4)	2 (1, 3)
DRD+	count			322	321
	time_stop			22 (14, 33)	21 (13, 34)
	n_trt			39 (25, 74)	37 (26, 69)
	n_control			45 (24, 79)	43 (25, 74)
	post_p			1 (0.99, 1)	1 (0.99, 1)
	order			2 (1, 3)	2 (1, 3)
TEfus+	count	4	2	24	24
	time_stop	13 (9, 16)	12 (12, 13)	14 (10, 28)	15 (10, 24)
	n_trt	30 (26, 40)	26 (25, 28)	32 (27, 53)	30 (25, 51)
	n_control	28 (23, 50)	34 (32, 36)	40 (23, 75)	40 (27, 72)
	post_p	0.94 (0.87, 0.97)	0.95 (0.91, 0.99)	0.98 (0.92, 1)	1 (0.96, 1)
	order	1.5 (1, 2.7)	2.5 (1.3, 3.7)	2 (1, 3)	2 (1, 3)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	6	4	1
	time_stop	13 (6, 25)	14 (4, 28)	4 (4, 4)
	n_trt	65 (40, 142)	77 (29, 153)	30 (30, 30)
	n_control	94 (37, 196)	110 (29, 236)	29 (29, 29)
	post_p	0.05 (0.02, 0.17)	0.03 (0.01, 0.09)	0.09 (0.09, 0.09)
	order	2 (1, 3.5)	3.5 (1, 6)	1 (1, 1)
TP53- & AR-	count	203	216	9	6
	time_stop	17 (10, 30)	17 (10, 31)	10 (9, 14)	11 (10, 18)
	n_trt	43 (26, 86)	44 (26, 92)	26 (25, 32)	27 (26, 42)
	n_control	46 (23, 95)	46 (24, 100)	28 (24, 37)	32 (24, 46)
	post_p	0.16 (0.05, 0.26)	0.16 (0.04, 0.28)	0.16 (0.03, 0.23)	0.18 (0.09, 0.25)
	order	1 (1, 3)	1 (1, 3)	1 (1, 1.2)	1 (1, 3)
TP53+	count	75	49	2	1
	time_stop	18 (9, 30)	19 (9, 32)	11 (11, 11)	8 (8, 8)
	n_trt	47 (28, 96)	59 (27, 100)	28 (26, 31)	28 (28, 28)
	n_control	49 (26, 102)	58 (25, 104)	34 (32, 37)	13 (13, 13)
	post_p	0.09 (0.02, 0.19)	0.09 (0.02, 0.19)	0.1 (0.07, 0.13)	0.21 (0.21, 0.21)
	order	2 (1, 3)	2 (1, 3)	1 (1, 1)	1 (1, 1)
DRD+	count	173	160
	time_stop	23 (13, 33)	23 (15, 34)
	n_trt	41 (26, 68)	42 (26, 71)
	n_control	47 (24, 79)	46 (27, 78)
	post_p	0.08 (0.01, 0.22)	0.08 (0.01, 0.22)
	order	2 (1, 4)	2 (1, 4)
TEfus+	count	64	45	1	2
	time_stop	15 (11, 33)	20 (12, 30)	18 (18, 18)	9 (8, 10)
	n_trt	36 (25, 75)	47 (30, 75)	47 (47, 47)	26 (25, 27)
	n_control	37 (23, 96)	52 (28, 91)	45 (45, 45)	22 (18, 26)
	post_p	0.06 (0, 0.17)	0.07 (0.02, 0.19)	0.08 (0.08, 0.08)	0.05 (0.04, 0.06)
	order	2 (1, 4)	2 (1, 4)	1 (1, 1)	1 (1, 1)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13
		time	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)	15 (6, 28)
		n	14 (8, 40)	5 (1, 10)	13 (6, 29)	6 (2, 24)	3 (1, 8)	3 (1, 9)	3 (0, 7)	3 (0, 7)	5 (1, 12)	3 (1, 8)	4 (0, 7)	3 (0, 8)	2 (0, 6)	2 (0, 6)	3 (0, 6)	3 (1, 6)
		post_p	0.68 (0.52, 0.9)	0.64 (0.53, 0.77)	0.63 (0.53, 0.77)	0.57 (0.52, 0.71)	0.61 (0.51, 0.86)	0.66 (0.52, 0.86)	0.65 (0.53, 0.85)	0.69 (0.53, 0.86)	0.67 (0.55, 0.96)	0.56 (0.51, 0.79)	0.7 (0.56, 0.89)	0.58 (0.55, 0.74)	0.62 (0.58, 0.89)	0.72 (0.56, 0.88)	0.59 (0.52, 0.84)	0.75 (0.56, 0.88)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.085 (0.063, 0.096)	0.071 (0, 0.106)	0.1 (0.05, 0.13)	0.087 (0.008, 0.131)	0.034 (0, 0.097)	0.023 (0, 0.052)	0.015 (0, 0.063)	0.021 (0, 0.072)	0.034 (0, 0.109)	0.087 (0, 0.134)	0.048 (0, 0.071)	0.084 (0, 0.129)	0.011 (0, 0.064)	0 (0, 0.036)	0 (0, 0.078)	0 (0, 0.043)
	Hormone_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)
		n	7 (6, 9)	0 (0, 2)	4 (2, 5)	2 (1, 4)	0 (0, 1)	1 (1, 2)	0 (0, 1)	0 (0, 2)	0 (0, 2)	2 (0, 2)	1 (1, 2)	2 (0, 3)	0 (0, 2)	1 (0, 2)	2 (1, 2)	0 (0, 2)
		post_p	0.67 (0.56, 0.76)	0.88 (0.88, 0.88)	0.69 (0.63, 0.79)	0.58 (0.56, 0.62)	0.59 (0.57, 0.61)	0.61 (0.55, 0.66)	0.52 (0.52, 0.52)	0.78 (0.78, 0.78)	0.66 (0.61, 0.71)	0.7 (0.67, 0.74)	0.56 (0.56, 0.56)	0.57 (0.57, 0.57)	NA (NA, NA)	0.56 (0.56, 0.56)	0.56 (0.53, 0.59)	0.67 (0.67, 0.67)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.054 (0.015, 0.1)	0.09 (0.09, 0.09)	0 (0, 0.05)	0 (0, 0)	0 (0, 0)	0 (0, 0.303)	0.191 (0.191, 0.191)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1.006)	0 (0, 0.245)	0.227 (0.045, 0.408)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Niraparib	count	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19
		time	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)	22 (5, 34)
		n	21 (6, 51)	4 (1, 15)	18 (4, 31)	9 (3, 21)	5 (2, 8)	3 (1, 10)	3 (1, 7)	2 (0, 7)	6 (1, 12)	6 (1, 10)	5 (1, 12)	4 (1, 11)	3 (1, 6)	4 (2, 7)	3 (0, 6)	3 (1, 8)
		post_p	0.68 (0.61, 0.82)	0.63 (0.51, 0.77)	0.66 (0.53, 0.87)	0.62 (0.53, 0.82)	0.73 (0.64, 0.94)	0.82 (0.59, 0.94)	0.73 (0.57, 0.9)	0.75 (0.65, 0.93)	0.6 (0.51, 0.74)	0.59 (0.51, 0.8)	0.7 (0.54, 0.83)	0.63 (0.52, 0.9)	0.64 (0.51, 0.93)	0.76 (0.59, 0.9)	0.58 (0.52, 0.94)	0.72 (0.59, 0.86)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.1 (0.053, 0.112)	0.071 (0, 0.105)	0.088 (0.033, 0.11)	0.091 (0.043, 0.118)	0.029 (0, 0.068)	0.036 (0, 0.081)	0.039 (0, 0.079)	0.017 (0, 0.037)	0.089 (0, 0.112)	0.091 (0.023, 0.122)	0.066 (0, 0.13)	0.043 (0, 0.114)	0.023 (0, 0.078)	0.017 (0, 0.051)	0.036 (0, 0.103)	0.018 (0, 0.051)
	Taxel_therapies	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	10 (5, 15)	2 (0, 4)	5 (4, 6)	3 (3, 3)	2 (1, 2)	0 (0, 0)	0 (0, 0)	2 (0, 4)	2 (1, 2)	2 (1, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (0, 2)	1 (0, 2)
		post_p	0.64 (0.56, 0.73)	0.66 (0.66, 0.66)	0.67 (0.6, 0.74)	0.52 (0.52, 0.53)	0.65 (0.58, 0.72)	NA (NA, NA)	NA (NA, NA)	0.64 (0.64, 0.64)	0.56 (0.54, 0.57)	0.6 (0.55, 0.66)	0.57 (0.57, 0.57)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.58 (0.58, 0.58)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.013 (0.003, 0.024)	0.116 (0.116, 0.116)	0 (0, 0)	0.055 (0.011, 0.1)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)
DRD+	Carboplatin	count					322	322	322	322					322	322	322	322
		time					22 (14, 33)	22 (14, 33)	22 (14, 33)	22 (14, 33)					22 (14, 33)	22 (14, 33)	22 (14, 33)	22 (14, 33)
		n					7 (3, 15)	7 (3, 15)	4 (1, 9)	4 (2, 10)					4 (1, 9)	4 (2, 9)	4 (2, 9)	4 (2, 9)
		post_p					0.82 (0.65, 0.98)	0.83 (0.63, 0.97)	0.74 (0.54, 0.93)	0.75 (0.55, 0.92)					0.75 (0.54, 0.93)	0.76 (0.55, 0.92)	0.74 (0.56, 0.92)	0.75 (0.54, 0.93)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.032 (0, 0.059)	0.031 (0, 0.061)	0.03 (0, 0.08)	0.032 (0, 0.069)					0.029 (0, 0.066)	0.028 (0, 0.073)	0.031 (0, 0.067)	0.03 (0, 0.084)
	Niraparib	count					321	321	321	321					321	321	321	321
		time					21 (13, 34)	21 (13, 34)	21 (13, 34)	21 (13, 34)					21 (13, 34)	21 (13, 34)	21 (13, 34)	21 (13, 34)
		n					7 (3, 15)	6 (3, 14)	4 (1, 9)	4 (1, 9)					4 (2, 8)	4 (2, 8)	4 (1, 9)	4 (1, 9)
		post_p					0.82 (0.61, 0.99)	0.85 (0.64, 0.97)	0.75 (0.57, 0.93)	0.76 (0.54, 0.93)					0.74 (0.54, 0.94)	0.74 (0.53, 0.92)	0.74 (0.54, 0.93)	0.75 (0.54, 0.93)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.03 (0, 0.062)	0.031 (0, 0.063)	0.029 (0, 0.069)	0.027 (0, 0.06)					0.028 (0, 0.073)	0.027 (0, 0.068)	0.026 (0, 0.076)	0.029 (0, 0.066)
TEfus+	Carboplatin	count		24		24		24		24		24		24		24		24
		time		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)		14 (10, 28)
		n		4 (2, 11)		11 (6, 17)		3 (1, 7)		2 (0, 5)		4 (3, 7)		2 (1, 6)		3 (1, 4)		3 (1, 7)
		post_p		0.64 (0.52, 0.79)		0.79 (0.72, 0.94)		0.7 (0.55, 0.91)		0.61 (0.53, 0.77)		0.65 (0.54, 0.78)		0.63 (0.52, 0.8)		0.66 (0.53, 0.85)		0.71 (0.58, 0.82)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.072 (0.007, 0.134)		0.068 (0.034, 0.097)		0.006 (0, 0.054)		0 (0, 0.056)		0.07 (0.012, 0.127)		0.048 (0, 0.125)		0.018 (0, 0.077)		0 (0, 0.091)
	Hormone_therapies	count		4		4		4		4		4		4		4		4
		time		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)		13 (9, 16)
		n		5 (3, 7)		7 (4, 15)		4 (3, 5)		2 (1, 3)		3 (2, 4)		2 (1, 4)		2 (0, 5)		4 (3, 4)
		post_p		0.81 (0.7, 0.86)		0.68 (0.62, 0.81)		0.58 (0.54, 0.65)		0.52 (0.51, 0.56)		0.68 (0.54, 0.87)		0.62 (0.57, 0.67)		0.64 (0.54, 0.73)		0.66 (0.55, 0.74)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.019 (0, 0.059)		0.048 (0.014, 0.083)		0.038 (0.008, 0.085)		0.075 (0.021, 0.101)		0.088 (0.061, 0.137)		0 (0, 0.069)		0.028 (0.006, 0.041)		0.045 (0.011, 0.073)
	Niraparib	count		24		24		24		24		24		24		24		24
		time		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)		15 (10, 24)
		n		4 (1, 6)		8 (4, 17)		5 (1, 9)		3 (1, 5)		3 (2, 7)		4 (2, 7)		3 (2, 6)		2 (1, 5)
		post_p		0.67 (0.54, 0.83)		0.76 (0.7, 0.89)		0.82 (0.63, 0.92)		0.68 (0.53, 0.86)		0.7 (0.56, 0.81)		0.7 (0.54, 0.78)		0.72 (0.53, 0.84)		0.65 (0.54, 0.83)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.055 (0, 0.089)		0.064 (0.035, 0.091)		0 (0, 0.039)		0 (0, 0.075)		0.077 (0, 0.11)		0.07 (0, 0.124)		0.017 (0, 0.069)		0.034 (0, 0.072)
	Taxel_therapies	count		2		2		2		2		2		2		2		2
		time		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)		12 (12, 13)
		n		6 (5, 6)		10 (9, 12)		2 (1, 4)		1 (1, 1)		4 (3, 4)		2 (0, 3)		2 (1, 2)		0 (0, 1)
		post_p		0.63 (0.53, 0.73)		0.87 (0.86, 0.87)		0.83 (0.83, 0.83)		0.66 (0.65, 0.68)		0.7 (0.7, 0.71)		0.62 (0.62, 0.62)		0.62 (0.61, 0.63)		0.55 (0.55, 0.55)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.06 (0.032, 0.087)		0.061 (0.058, 0.064)		0.119 (0.119, 0.119)		0 (0, 0)		0.103 (0.061, 0.145)		0.052 (0.052, 0.052)		0.04 (0.008, 0.073)		0 (0, 0)
TP53- & AR-	Carboplatin	count	134	134			134	134
		time	18 (9, 29)	18 (9, 29)			18 (9, 29)	18 (9, 29)
		n	31 (17, 56)	5 (2, 12)			5 (2, 13)	5 (2, 13)
		post_p	0.77 (0.71, 0.92)	0.71 (0.53, 0.87)			0.78 (0.58, 0.94)	0.78 (0.58, 0.96)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.088 (0.061, 0.115)	0.07 (0, 0.118)			0.031 (0, 0.057)	0.031 (0, 0.061)
	Hormone_therapies	count	9	9			9	9
		time	12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)
		n	18 (16, 25)	4 (3, 5)			4 (2, 5)	4 (2, 10)
		post_p	0.82 (0.8, 0.9)	0.6 (0.51, 0.77)			0.67 (0.53, 0.71)	0.63 (0.54, 0.84)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.079 (0.051, 0.098)	0.058 (0, 0.108)			0.042 (0, 0.114)	0.029 (0, 0.062)
	Niraparib	count	151	151			151	151
		time	15 (9, 30)	15 (9, 30)			15 (9, 30)	15 (9, 30)
		n	27 (16, 55)	4 (1, 12)			5 (2, 12)	5 (2, 10)
		post_p	0.76 (0.71, 0.9)	0.7 (0.53, 0.84)			0.8 (0.58, 0.95)	0.78 (0.6, 0.95)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.088 (0.054, 0.11)	0.073 (0, 0.104)			0.025 (0, 0.056)	0.025 (0, 0.059)
	Taxel_therapies	count	11	11			11	11
		time	12 (10, 19)	12 (10, 19)			12 (10, 19)	12 (10, 19)
		n	19 (14, 30)	3 (2, 6)			3 (2, 5)	4 (3, 5)
		post_p	0.8 (0.74, 0.9)	0.69 (0.51, 0.84)			0.64 (0.53, 0.76)	0.68 (0.56, 0.77)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.087 (0.067, 0.098)	0.048 (0, 0.173)			0 (0, 0.076)	0.053 (0, 0.119)
TP53+	Carboplatin	count			25	25			25	25			25	25			25	25
		time			18 (9, 27)	18 (9, 27)			18 (9, 27)	18 (9, 27)			18 (9, 27)	18 (9, 27)			18 (9, 27)	18 (9, 27)
		n			14 (7, 29)	10 (4, 18)			3 (1, 7)	3 (0, 8)			4 (0, 7)	4 (1, 8)			3 (0, 6)	2 (1, 5)
		post_p			0.76 (0.73, 0.88)	0.75 (0.6, 0.85)			0.73 (0.56, 0.92)	0.76 (0.59, 0.93)			0.64 (0.51, 0.77)	0.74 (0.54, 0.86)			0.68 (0.52, 0.91)	0.66 (0.54, 0.9)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.077 (0.033, 0.111)	0.074 (0.014, 0.099)			0.018 (0, 0.072)	0.025 (0, 0.046)			0.077 (0, 0.145)	0.06 (0, 0.107)			0.009 (0, 0.061)	0 (0, 0.091)
	Hormone_therapies	count			6	6			6	6			6	6			6	6
		time			8 (7, 9)	8 (7, 9)			8 (7, 9)	8 (7, 9)			8 (7, 9)	8 (7, 9)			8 (7, 9)	8 (7, 9)
		n			12 (9, 12)	6 (3, 8)			2 (0, 3)	1 (0, 2)			4 (3, 5)	2 (0, 2)			2 (1, 3)	0 (0, 2)
		post_p			0.82 (0.77, 0.88)	0.72 (0.64, 0.86)			0.53 (0.51, 0.55)	0.65 (0.62, 0.68)			0.7 (0.67, 0.83)	0.54 (0.54, 0.6)			0.52 (0.51, 0.59)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.042 (0.029, 0.071)	0.022 (0, 0.091)			0 (0, 0)	0 (0, 0)			0.061 (0, 0.155)	0.064 (0, 0.144)			0.08 (0, 0.225)	0 (0, 0.506)
	Niraparib	count			27	27			27	27			27	27			27	27
		time			16 (10, 29)	16 (10, 29)			16 (10, 29)	16 (10, 29)			16 (10, 29)	16 (10, 29)			16 (10, 29)	16 (10, 29)
		n			19 (8, 32)	11 (5, 21)			3 (1, 7)	3 (1, 6)			5 (1, 9)	4 (2, 7)			3 (1, 4)	2 (1, 5)
		post_p			0.78 (0.71, 0.88)	0.78 (0.71, 0.87)			0.77 (0.62, 0.94)	0.69 (0.54, 0.84)			0.71 (0.56, 0.87)	0.69 (0.53, 0.83)			0.63 (0.52, 0.81)	0.67 (0.52, 0.91)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.073 (0.032, 0.104)	0.079 (0.036, 0.097)			0.016 (0, 0.048)	0 (0, 0.048)			0.059 (0, 0.105)	0.07 (0, 0.116)			0.016 (0, 0.085)	0 (0, 0.057)
	Taxel_therapies	count			5	5			5	5			5	5			5	5
		time			10 (9, 11)	10 (9, 11)			10 (9, 11)	10 (9, 11)			10 (9, 11)	10 (9, 11)			10 (9, 11)	10 (9, 11)
		n			10 (9, 15)	7 (6, 9)			1 (0, 3)	2 (1, 4)			3 (1, 4)	1 (0, 3)			1 (1, 3)	3 (0, 4)
		post_p			0.79 (0.74, 0.85)	0.72 (0.68, 0.76)			0.53 (0.52, 0.86)	0.55 (0.52, 0.71)			0.77 (0.67, 0.82)	0.84 (0.62, 0.88)			0.58 (0.53, 0.61)	0.55 (0.53, 0.7)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.047 (0.034, 0.053)	0.055 (0.05, 0.085)			0.028 (0.006, 0.127)	0.061 (0, 0.131)			0 (0, 0.042)	0 (0, 0)			0 (0, 0.05)	0.068 (0.051, 0.115)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)	4 (4, 4)
		n	6 (6, 6)	1 (1, 1)	6 (6, 6)	3 (3, 3)	0 (0, 0)	1 (1, 1)	0 (0, 0)	2 (2, 2)	3 (3, 3)	0 (0, 0)	0 (0, 0)	1 (1, 1)	0 (0, 0)	4 (4, 4)	1 (1, 1)	2 (2, 2)
		post_p	0.05 (0.05, 0.05)	0.48 (0.48, 0.48)	0.19 (0.19, 0.19)	0.47 (0.47, 0.47)	NA (NA, NA)	0.22 (0.22, 0.22)	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	0.45 (0.45, 0.45)	NA (NA, NA)	0.43 (0.43, 0.43)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.257 (0.257, 0.257)	0 (0, 0)	0.211 (0.211, 0.211)	0.141 (0.141, 0.141)	NA (NA, NA)	0.955 (0.955, 0.955)	NA (NA, NA)	0 (0, 0)	0.141 (0.141, 0.141)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Hormone_therapies	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
		time	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)	13 (6, 25)
		n	19 (12, 28)	4 (2, 6)	8 (4, 26)	5 (4, 13)	3 (2, 6)	2 (0, 8)	1 (0, 4)	2 (0, 7)	3 (2, 6)	4 (0, 6)	4 (1, 9)	2 (0, 8)	2 (0, 7)	2 (0, 5)	2 (0, 6)	3 (0, 4)
		post_p	0.33 (0.05, 0.44)	0.39 (0.31, 0.45)	0.38 (0.24, 0.46)	0.41 (0.31, 0.49)	0.41 (0.27, 0.44)	0.39 (0.16, 0.41)	0.42 (0.19, 0.47)	0.39 (0.32, 0.45)	0.41 (0.29, 0.48)	0.38 (0.27, 0.42)	0.36 (0.1, 0.45)	0.4 (0.34, 0.46)	0.31 (0.23, 0.43)	0.37 (0.24, 0.44)	0.29 (0.24, 0.43)	0.3 (0.24, 0.37)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.124 (0.096, 0.181)	0.137 (0.085, 0.167)	0.149 (0.115, 0.295)	0.128 (0.071, 0.207)	0.118 (0.086, 0.131)	0.164 (0.1, 0.511)	0.129 (0.033, 0.242)	0.112 (0.067, 0.846)	0.18 (0.118, 0.389)	0.142 (0.037, 0.299)	0.168 (0.114, 0.411)	0.134 (0.107, 0.331)	0.163 (0.092, 0.888)	0.146 (0.117, 0.212)	0.204 (0.105, 0.245)	0.118 (0.11, 0.151)
	Taxel_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)	14 (4, 28)
		n	22 (6, 54)	6 (3, 10)	12 (5, 22)	8 (3, 14)	4 (2, 7)	2 (0, 6)	1 (0, 1)	2 (1, 4)	4 (1, 7)	2 (0, 4)	2 (0, 5)	2 (0, 3)	4 (1, 6)	2 (2, 3)	4 (1, 8)	1 (0, 5)
		post_p	0.35 (0.16, 0.46)	0.36 (0.32, 0.44)	0.37 (0.26, 0.47)	0.33 (0.2, 0.46)	0.28 (0.22, 0.39)	0.35 (0.33, 0.36)	0.41 (0.3, 0.48)	0.34 (0.17, 0.42)	0.24 (0.21, 0.41)	0.27 (0.14, 0.38)	0.28 (0.25, 0.39)	0.32 (0.26, 0.36)	0.42 (0.17, 0.45)	0.25 (0.14, 0.4)	0.37 (0.22, 0.43)	0.24 (0.16, 0.32)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.14 (0.106, 0.2)	0.133 (0.097, 0.185)	0.18 (0.128, 0.262)	0.128 (0.112, 0.151)	0.143 (0.113, 0.32)	0.173 (0.123, 3.05)	0.174 (0.035, 1.541)	0.224 (0.027, 0.437)	0.306 (0.262, 0.433)	0.628 (0.361, 1.226)	0.184 (0.136, 0.58)	0.225 (0.162, 0.746)	0.263 (0.138, 0.841)	0.297 (0.02, 0.554)	0.136 (0.118, 0.202)	0.183 (0.165, 0.202)
DRD+	Hormone_therapies	count					173	173	173	173					173	173	173	173
		time					23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)					23 (13, 33)	23 (13, 33)	23 (13, 33)	23 (13, 33)
		n					7 (3, 14)	7 (3, 13)	5 (2, 9)	4 (1, 9)					5 (2, 9)	4 (2, 8)	4 (1, 8)	5 (1, 9)
		post_p					0.28 (0.11, 0.47)	0.28 (0.09, 0.45)	0.3 (0.11, 0.47)	0.31 (0.13, 0.46)					0.33 (0.13, 0.47)	0.33 (0.12, 0.45)	0.33 (0.14, 0.47)	0.35 (0.14, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.131 (0.086, 0.231)	0.139 (0.089, 0.27)	0.136 (0.079, 0.307)	0.144 (0.08, 0.346)					0.125 (0.074, 0.293)	0.133 (0.071, 0.289)	0.127 (0.07, 0.303)	0.14 (0.085, 0.308)
	Taxel_therapies	count					160	160	160	160					160	160	160	160
		time					23 (15, 34)	23 (15, 34)	23 (15, 34)	23 (15, 34)					23 (15, 34)	23 (15, 34)	23 (15, 34)	23 (15, 34)
		n					6 (2, 14)	6 (3, 13)	5 (2, 9)	4 (2, 9)					5 (2, 9)	5 (2, 10)	5 (2, 9)	5 (1, 9)
		post_p					0.3 (0.11, 0.46)	0.3 (0.09, 0.46)	0.34 (0.19, 0.47)	0.3 (0.14, 0.47)					0.34 (0.13, 0.47)	0.32 (0.11, 0.47)	0.32 (0.11, 0.47)	0.3 (0.14, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.126 (0.079, 0.354)	0.132 (0.086, 0.252)	0.124 (0.081, 0.277)	0.129 (0.077, 0.289)					0.128 (0.076, 0.341)	0.137 (0.082, 0.334)	0.133 (0.076, 0.313)	0.14 (0.084, 0.366)
TEfus+	Carboplatin	count		1		1		1		1		1		1		1		1
		time		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)		18 (18, 18)
		n		11 (11, 11)		14 (14, 14)		12 (12, 12)		2 (2, 2)		2 (2, 2)		2 (2, 2)		3 (3, 3)		1 (1, 1)
		post_p		0.24 (0.24, 0.24)		0.19 (0.19, 0.19)		0.4 (0.4, 0.4)		0.5 (0.5, 0.5)		0.43 (0.43, 0.43)		0.16 (0.16, 0.16)		0.4 (0.4, 0.4)		0.35 (0.35, 0.35)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.14 (0.14, 0.14)		0.143 (0.143, 0.143)		0.06 (0.06, 0.06)		0.074 (0.074, 0.074)		0.147 (0.147, 0.147)		0.282 (0.282, 0.282)		0.073 (0.073, 0.073)		0.807 (0.807, 0.807)
	Hormone_therapies	count		64		64		64		64		64		64		64		64
		time		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)		15 (11, 33)
		n		5 (3, 11)		10 (6, 23)		5 (2, 10)		3 (1, 8)		4 (2, 8)		4 (1, 9)		3 (1, 7)		3 (1, 7)
		post_p		0.39 (0.13, 0.48)		0.31 (0.13, 0.47)		0.26 (0.09, 0.44)		0.34 (0.13, 0.46)		0.37 (0.17, 0.48)		0.3 (0.09, 0.46)		0.34 (0.19, 0.46)		0.33 (0.19, 0.46)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.145 (0.094, 0.267)		0.146 (0.099, 0.241)		0.157 (0.089, 0.296)		0.154 (0.062, 0.589)		0.165 (0.101, 0.466)		0.177 (0.103, 0.417)		0.146 (0.061, 0.38)		0.145 (0.082, 0.335)
	Niraparib	count		2		2		2		2		2		2		2		2
		time		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)		9 (8, 10)
		n		3 (3, 3)		10 (8, 12)		3 (2, 4)		0 (0, 0)		4 (2, 5)		2 (1, 3)		3 (2, 4)		1 (0, 2)
		post_p		0.4 (0.34, 0.46)		0.29 (0.23, 0.34)		0.35 (0.26, 0.45)		NA (NA, NA)		0.28 (0.23, 0.33)		0.41 (0.36, 0.46)		0.25 (0.1, 0.4)		0.47 (0.47, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.125 (0.084, 0.166)		0.123 (0.101, 0.146)		0.123 (0.076, 0.17)		NA (NA, NA)		0.344 (0.286, 0.401)		1.454 (0.364, 2.543)		0.267 (0.224, 0.31)		0 (0, 0)
	Taxel_therapies	count		45		45		45		45		45		45		45		45
		time		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)		20 (12, 30)
		n		7 (2, 12)		12 (6, 22)		5 (2, 14)		4 (0, 7)		5 (2, 12)		5 (2, 9)		4 (2, 8)		4 (2, 8)
		post_p		0.4 (0.18, 0.48)		0.37 (0.19, 0.48)		0.31 (0.13, 0.42)		0.35 (0.24, 0.45)		0.32 (0.14, 0.47)		0.38 (0.18, 0.49)		0.32 (0.2, 0.45)		0.34 (0.14, 0.47)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.139 (0.09, 0.283)		0.131 (0.107, 0.185)		0.127 (0.077, 0.364)		0.13 (0.081, 0.367)		0.164 (0.104, 0.431)		0.182 (0.106, 0.264)		0.136 (0.083, 0.386)		0.141 (0.097, 0.313)
TP53- & AR-	Carboplatin	count	9	9			9	9
		time	10 (9, 14)	10 (9, 14)			10 (9, 14)	10 (9, 14)
		n	17 (14, 23)	4 (2, 7)			4 (3, 5)	4 (0, 6)
		post_p	0.22 (0.13, 0.35)	0.35 (0.21, 0.44)			0.43 (0.26, 0.47)	0.44 (0.23, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.141 (0.12, 0.183)	0.137 (0.081, 0.524)			0.102 (0.053, 0.146)	0.11 (0.054, 0.204)
	Hormone_therapies	count	203	203			203	203
		time	17 (10, 30)	17 (10, 30)			17 (10, 30)	17 (10, 30)
		n	26 (15, 56)	6 (2, 11)			6 (3, 12)	5 (2, 11)
		post_p	0.3 (0.11, 0.46)	0.39 (0.15, 0.48)			0.34 (0.09, 0.48)	0.31 (0.12, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.128 (0.102, 0.172)	0.145 (0.096, 0.325)			0.128 (0.079, 0.266)	0.14 (0.085, 0.305)
	Niraparib	count	6	6			6	6
		time	11 (10, 18)	11 (10, 18)			11 (10, 18)	11 (10, 18)
		n	20 (18, 26)	3 (1, 8)			3 (1, 5)	4 (1, 7)
		post_p	0.34 (0.12, 0.48)	0.3 (0.17, 0.42)			0.41 (0.33, 0.47)	0.45 (0.34, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.118 (0.095, 0.162)	0.302 (0.097, 0.358)			0.112 (0.101, 0.801)	0.122 (0.035, 0.172)
	Taxel_therapies	count	216	216			216	216
		time	17 (10, 31)	17 (10, 31)			17 (10, 31)	17 (10, 31)
		n	28 (16, 56)	6 (2, 13)			5 (2, 12)	6 (3, 13)
		post_p	0.32 (0.09, 0.47)	0.36 (0.12, 0.48)			0.33 (0.11, 0.47)	0.31 (0.1, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.127 (0.104, 0.179)	0.152 (0.095, 0.336)			0.133 (0.079, 0.327)	0.13 (0.081, 0.338)
TP53+	Carboplatin	count			2	2			2	2			2	2			2	2
		time			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n			10 (8, 13)	6 (4, 9)			2 (1, 2)	2 (0, 4)			4 (2, 5)	3 (1, 5)			2 (0, 3)	0 (0, 0)
		post_p			0.35 (0.23, 0.47)	0.33 (0.25, 0.41)			0.4 (0.32, 0.48)	0.46 (0.46, 0.46)			0.39 (0.34, 0.44)	0.31 (0.24, 0.38)			0.28 (0.28, 0.28)	NA (NA, NA)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.131 (0.116, 0.146)	0.156 (0.136, 0.176)			14.383 (2.877, 25.889)	0.07 (0.07, 0.07)			0.132 (0.131, 0.133)	0.248 (0.14, 0.356)			0.131 (0.131, 0.131)	NA (NA, NA)
	Hormone_therapies	count			75	75			75	75			75	75			75	75
		time			18 (9, 30)	18 (9, 30)			18 (9, 30)	18 (9, 30)			18 (9, 30)	18 (9, 30)			18 (9, 30)	18 (9, 30)
		n			15 (9, 32)	10 (4, 24)			4 (0, 8)	3 (1, 8)			5 (1, 11)	4 (1, 8)			4 (1, 8)	3 (1, 9)
		post_p			0.33 (0.11, 0.48)	0.35 (0.17, 0.49)			0.33 (0.14, 0.46)	0.33 (0.15, 0.44)			0.35 (0.16, 0.48)	0.36 (0.15, 0.49)			0.33 (0.18, 0.48)	0.35 (0.12, 0.46)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.133 (0.105, 0.198)	0.135 (0.107, 0.23)			0.131 (0.079, 0.334)	0.151 (0.069, 0.417)			0.156 (0.091, 0.35)	0.174 (0.102, 0.352)			0.125 (0.048, 0.316)	0.14 (0.088, 0.344)
	Niraparib	count			1	1			1	1			1	1			1	1
		time			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)
		n			4 (4, 4)	9 (9, 9)			2 (2, 2)	3 (3, 3)			5 (5, 5)	3 (3, 3)			1 (1, 1)	1 (1, 1)
		post_p			0.25 (0.25, 0.25)	0.28 (0.28, 0.28)			NA (NA, NA)	0.48 (0.48, 0.48)			0.34 (0.34, 0.34)	0.44 (0.44, 0.44)			0.46 (0.46, 0.46)	0.41 (0.41, 0.41)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.287 (0.287, 0.287)	0.176 (0.176, 0.176)			0 (0, 0)	0 (0, 0)			0.106 (0.106, 0.106)	0.155 (0.155, 0.155)			0 (0, 0)	0.257 (0.257, 0.257)
	Taxel_therapies	count			49	49			49	49			49	49			49	49
		time			19 (9, 32)	19 (9, 32)			19 (9, 32)	19 (9, 32)			19 (9, 32)	19 (9, 32)			19 (9, 32)	19 (9, 32)
		n			18 (8, 29)	13 (5, 22)			4 (1, 8)	4 (1, 7)			4 (1, 10)	5 (1, 10)			5 (0, 9)	4 (1, 9)
		post_p			0.29 (0.12, 0.47)	0.36 (0.15, 0.48)			0.33 (0.16, 0.45)	0.35 (0.2, 0.47)			0.34 (0.18, 0.45)	0.39 (0.14, 0.48)			0.34 (0.15, 0.48)	0.31 (0.18, 0.46)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.138 (0.11, 0.181)	0.14 (0.108, 0.25)			0.115 (0.063, 0.317)	0.125 (0.081, 0.379)			0.161 (0.11, 0.373)	0.167 (0.088, 0.383)			0.129 (0.06, 0.339)	0.151 (0.097, 0.579)